In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model.
Infection associated with orthopedic implants often results in bone loss and requires surgical removal of the implant. The aim of this study was to evaluate morphological changes of bone adjacent to a bacteria-colonized implant, with the aim of identifying temporal patterns that are characteristic o...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 13 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/29/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109274066&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109274066 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/29/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109274066 109274066 109274066 10.1155/2015/587857 109274066 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model. aug: au: Stadelmann, Vincent A. Potapova, Inga Camenisch, Karin Nehrbass, Dirk Richards, R. Geoff Moriarty, T. Fintan affil: AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos-Platz, Switzerland sug: subj: Osteomyelitis Tomography Methods Monitoring, Physiologic Animal Studies Rats Switzerland Academic Medical Centers Early Diagnosis Microbial Culture and Sensitivity Tests Pearson's Correlation Coefficient Analysis of Variance Post Hoc Analysis Linear Regression Funding Source ab: Infection associated with orthopedic implants often results in bone loss and requires surgical removal of the implant. The aim of this study was to evaluate morphological changes of bone adjacent to a bacteria-colonized implant, with the aim of identifying temporal patterns that are characteristic of infection. In an in vivo study with rats, bone changes were assessed using in vivo microCT at 7 time points during a one-month postoperative period. The rats received either a sterile or Staphylococcus aureus-colonized polyetheretherketone screw in the tibia. Bone-implant contact, bone fraction, and bone changes (quiescent, resorbed, and new bone) were calculated from consecutive scans and validated against histomorphometry. The screw pullout strength was estimated from FE models and the results were validated against mechanical testing. In the sterile group, bone-implant contact, bone fraction, and mechanical fixation increased steadily until day 14 and then plateaued. In the infected group, they decreased rapidly. Bone formation was reduced while resorption was increased, with maximum effects observed within 6 days. In summary, the model presented is capable of evaluating the patterns of bone changes due to implant-related infections. The combined use of longitudinal in vivo microCT imaging and image-based finite element analysis provides characteristic signs of infection within 6 days. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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