Comparison of Second-Line Quadruple Therapies with or without Bismuth for Helicobacter pylori Infection.
The bismuth-based quadruple regimen has been applied in Helicobacter pylori rescue therapy worldwide. The non-bismuth-based quadruple therapy or “concomitant therapy” is an alternative option in first-line eradication but has not been used in second-line therapy. Discovering a valid regimen for resc...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 7 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
5/18/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109274258&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109274258 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 5/18/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109274258 109274258 109274258 10.1155/2015/163960 109274258 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Comparison of Second-Line Quadruple Therapies with or without Bismuth for Helicobacter pylori Infection. aug: au: Jheng, Guang-Hong Wu, I-Chen Shih, Hsiang-Yao Wu, Meng-Chieh Kuo, Fu-Chen Hu, Huang-Ming Liu, Chung-Jung Hsu, Wen-Hung Hu, Chi-Tan Bair, Ming-Jong Kuo, Chao-Hung Wu, Deng-Chyang Hsu, Ping-I affil: Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan sug: subj: Helicobacter Infections Drug Therapy Bismuth Administration and Dosage Human Randomized Controlled Trials Random Assignment Rabeprazole Sodium Tetracycline Metronidazole Amoxicillin Taiwan Funding Source Questionnaires Chi Square Test T-Tests Male Female Middle Age Aged Data Analysis Software Middle Aged: 45-64 years Aged: 65+ years Male Female ab: The bismuth-based quadruple regimen has been applied in Helicobacter pylori rescue therapy worldwide. The non-bismuth-based quadruple therapy or “concomitant therapy” is an alternative option in first-line eradication but has not been used in second-line therapy. Discovering a valid regimen for rescue therapy in bismuth-unavailable countries is important. We conducted a randomized controlled trial to compare the efficacies of the standard quadruple therapy and a modified concomitant regimen. One hundred and twenty-four patients were randomly assigned into two groups: RBTM (rabeprozole 20 mg bid., bismuth subcitrate 120 mg qid, tetracycline 500 mg qid, and metronidazole 250 mg qid) and RATM (rabeprozole 20 mg bid., amoxicillin 1 g bid., tetracycline 500 mg qid, and metronidazole 250 mg qid) for 10 days. The eradication rate of the RBTM and RATM regimen was 92.1% and 90.2%, respectively, in intention-to-treat analysis. Patients in both groups had good compliance (~96%). The overall incidence of adverse events was higher in the RATM group (42.6% versus 22.2%, P=0.02), but only seven patients (11.5%) experienced grades 2-3 events. In conclusion, both regimens had good efficacy, compliance, and acceptable side effects. The 10-day RATM treatment could be an alternative rescue therapy in bismuth-unavailable countries. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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