Endoscopic Raman Spectroscopy for Molecular Fingerprinting of Gastric Cancer: Principle to Implementation.

Currently, positive endoscopic biopsy is the standard criterion for gastric cancer diagnosis but is invasive, often inconsistent, and delayed although early detection and early treatment is the most important policy. Raman spectroscopy is a spectroscopic technique based on inelastic scattering of mo...

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Publicado en:BioMed Research International Vol. 2015; pp. 1 - 10
Autor principal: Kim, Hyung Hun
Formato: equations & formulas pictorial review tables/charts Journal Article
Publicado: Wiley-Blackwell 5/27/2015
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 5/27/2015
      vid: 2015
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/2015/670121
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        atl: Endoscopic Raman Spectroscopy for Molecular Fingerprinting of Gastric Cancer: Principle to Implementation.
      aug:
        au: Kim, Hyung Hun
        affil: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
      sug:
        subj:
          Stomach Neoplasms Diagnosis
          Spectrum Analysis, Raman Utilization
          Molecular Diagnostic Techniques
          Endoscopy Methods
          Sensitivity and Specificity
          Early Diagnosis
          Stomach Neoplasms Epidemiology
          Spectrum Analysis, Raman Evaluation
          Funding Source
      ab: Currently, positive endoscopic biopsy is the standard criterion for gastric cancer diagnosis but is invasive, often inconsistent, and delayed although early detection and early treatment is the most important policy. Raman spectroscopy is a spectroscopic technique based on inelastic scattering of monochromatic light. Raman spectrum represents molecular composition of the interrogated volume providing a direct molecular fingerprint. Several investigations revealed that Raman spectroscopy can differentiate normal, dysplastic, and adenocarcinoma gastric tissue with high sensitivity and specificity. Moreover, this technique can indentify malignant ulcer and showed the capability to analyze the carcinogenesis process. Automated on-line Raman spectral diagnostic system raised possibility to use Raman spectroscopy in clinical field. Raman spectroscopy can be applied in many fields such as guiding a target biopsy, optical biopsy in bleeding prone situation, and delineating the margin of the lesion. With wide field technology, Raman spectroscopy is expected to have specific role in our future clinical field.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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