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A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration.

Objective. A novel injectable magnesium/calcium sulfate hemihydrate (Mg/CSH) composite with improved properties was reported here. Methods. Composition, setting time, injectability, compressive strength, and bioactivity in simulated body fluid (SBF) of the Mg/CSH composite were evaluated. Furthermor...

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Published in:BioMed Research International Vol. 2015; pp. 1 - 16
Main Authors: Zhang, Shanchuan, Yang, Ke, Cui, Fuzhai, Jiang, Yi, E, Lingling, Xu, Baohua, Liu, Hongchen
Format: pictorial research tables/charts Journal Article
Published: Wiley-Blackwell 6/3/2015
Online Access:View this record in EBSCOhost
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        23146133
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      jtl: BioMed Research International
      issn: 23146133
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      dt: 6/3/2015
      vid: 2015
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        109274466
        109274466
        109274466
        10.1155/2015/297437
        109274466
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        atl: A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration.
      aug:
        au:
          Zhang, Shanchuan
          Yang, Ke
          Cui, Fuzhai
          Jiang, Yi
          E, Lingling
          Xu, Baohua
          Liu, Hongchen
        affil: Center of Stomatology, China-Japan Friendship Hospital, Beijing 100029, China
      sug:
        subj:
          Bone Cements
          Magnesium
          Calcium
          Bone and Bones Metabolism
          Regeneration
          Funding Source
          Animal Studies
          Dogs
          Models, Biological
          In Vitro Studies
          Absorptiometry, Photon
          Descriptive Statistics
          One-Way Analysis of Variance
          Two-Way Analysis of Variance
          Post Hoc Analysis
          Reverse Transcriptase Polymerase Chain Reaction
      ab: Objective. A novel injectable magnesium/calcium sulfate hemihydrate (Mg/CSH) composite with improved properties was reported here. Methods. Composition, setting time, injectability, compressive strength, and bioactivity in simulated body fluid (SBF) of the Mg/CSH composite were evaluated. Furthermore, the cellular responses of canine bone marrow stromal cells (cBMSCs) and bone formation capacity after the implantation of Mg/CSH in tibia defects of canine were investigated. Results. Mg/CSH possessed a prolonged setting time and markedly improved injectability and mechanical property p<0.05. Mg/CSH samples showed better degradability than CSH in SBF after 21 days of soaking p<0.05. Moreover, the degrees of cell attachment, proliferation, and capability of osteogenic differentiation on the Mg/CSH specimens were higher than those on CSH, without significant cytotoxicity and with the increased proliferation index, ALP activity, and expression levels of integrin β1 and Coll I in cBMSCs p<0.05. Mg/CSH enhanced the efficiency of new bone formation at the tibia defect area, including the significantly elevated bone mineral density, bone area fraction, and Coll I expression level p<0.05. Conclusions. The results implied that this new injectable bone scaffold exhibited promising prospects for bone repair and had a great potential in bone tissue engineering.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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