Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.
The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β p...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 16 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
6/17/2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109274622&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109274622 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 6/17/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109274622 109274622 109274622 10.1155/2015/604385 109274622 ppf: 1 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma. aug: au: Wang, Wan-Jhen Wu, Yu-Sheng Chen, Sherwin Liu, Chi-Feng Chen, Shiu-Nan affil: College of Life Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Da’ an District, Taipei City 10617, Taiwan sug: subj: Lung Neoplasms Physiopathology Macrophages Physiology Mushroom Polysaccharides Animal Studies Mice Models, Biological Enzyme-Linked Immunosorbent Assay Polymerase Chain Reaction In Vitro Studies Data Analysis Software One-Way Analysis of Variance Post Hoc Analysis ab: The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum. In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|