Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects.
Objectives. The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaem...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 6 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
6/21/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109274638&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109274638 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 6/21/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109274638 109274638 109274638 10.1155/2015/196379 109274638 ppf: 1 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects. aug: au: Zhang, Yun Wang, Qiong Li, Quanzhong Lu, Ping affil: Department of Endocrinology, Henan Province People’s Hospital and Zhengzhou University People’s Hospital, 7 Weiwu Road, Zhengzhou, Henan 470003, China sug: subj: Diabetes Mellitus, Type 2 Hyperhomocysteinemia Risk Factors Thyroid Hormones Blood Thyroxine Blood Human Female Male Prospective Studies Cross Sectional Studies Thyrotropin Blood Sex Factors Age Factors Descriptive Statistics Logistic Regression Middle Age Aged Adult Data Analysis Software T-Tests Pearson's Correlation Coefficient Young Adult Aged, 80 and Over Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Aged, 80 & over Female Male ab: Objectives. The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaemia in a cohort of euthyroid diabetic subjects. Material and Methods. Two hundred and seventy-three euthyroid diabetic subjects (167 males and 106 females) were consecutively recruited in this cross-sectional study. Clinical and biomedical data was collected. Results. TSH level was higher in females than males. Compared to normal-homocysteine group, hyperhomocysteinaemia group was more likely to be elderly, males, with longer diabetes history, and with lower diastolic blood pressure. Free thyroxine (FT4) level was lower in hyperhomocysteinaemia group than in normal-homocysteine group; however, it was not statistically significant. Adjusted for age, sex, body mass index, duration of diabetes, blood pressure, fasting glucose, total cholesterol, and triglyceride in logistic regression analyses, hyperhomocysteinaemia was significantly correlated with FT4 (P=0.021). No significant association was found with TSH or free triiodothyronine. When analyzed in subjects with TSH < 2.5 uIU/mL separately, we got similar results. Conclusions. In conclusion, we identified a relation between hyperhomocysteinemia and FT4 in a group of euthyroid diabetic patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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