Correlation of CCNA1 Promoter Methylation with Malignant Tumors: A Meta-Analysis Introduction.
Epigenetic silencing of tumor suppressor genes by promoter methylation plays vital roles in the process of carcinogenesis. The purpose of this meta-analysis was to determine whether the aberrant methylation of cyclin A1 (CCNA1) may be of great significance to human malignant tumors. By searching bot...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 13 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1/15/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109280972&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109280972 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/15/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109280972 109280972 109280972 10.1155/2015/134027 109280972 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Correlation of CCNA1 Promoter Methylation with Malignant Tumors: A Meta-Analysis Introduction. aug: au: Yang, Bin Miao, Shuai Zhang, Le-Ning Sun, Hong-Bin Xu, Zhe-Nan Han, Chun-Shan affil: Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China sug: subj: Epigenomics Neoplasms Familial and Genetic Neoplasms Physiopathology DNA Methylation Human Systematic Review Meta Analysis Odds Ratio Confidence Intervals Data Analysis Software Case Control Studies Disease Progression PubMed Embase Cochrane Library CINAHL Database Linear Regression ab: Epigenetic silencing of tumor suppressor genes by promoter methylation plays vital roles in the process of carcinogenesis. The purpose of this meta-analysis was to determine whether the aberrant methylation of cyclin A1 (CCNA1) may be of great significance to human malignant tumors. By searching both English and Chinese language-based electronic databases carefully, we tabulated and analyzed parameters from each study. All human-associated case-control studies were included providing available data for CCNA1 methylation and reporting the adjusted odds ratios (ORs) and 95% confidence intervals (CI) conducted with the use of Version 12.0 STATA software. A total of 10 case-control studies (619 patients with cancers and 292 healthy controls) were included for the following statistical analysis. Pooled OR values from all articles revealed that the frequency of CCNA1 methylation in cancer tissues was significantly higher than those of normal tissues (P<0.001). Further ethnicity indicated that the frequency of CCNA1 methylation was correlated with the development of malignant tumors among all those included experimental subgroups (all P<0.05). These data from results indicated a significant connection of CCNA1 methylation with poor progression in human malignant tumors among both Caucasian and Asian populations. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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