Pathophysiology of pyoderma gangrenosum (PG): an updated review.
Pyoderma gangrenosum is a challenging skin condition to identify and treat because of its multifactorial pathogenesis. It is a rare cutaneous manifestation diagnosed clinically by exclusion of infection, neoplasia, thrombophilia, and other inflammatory conditions. Pathogenetic and treatment studies...
| Publicado en: | Journal of the American Academy of Dermatology Vol. 73; no. 4; pp. 691 - 699 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109445225&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109445225 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01909622 1ZF jtl: Journal of the American Academy of Dermatology issn: 01909622 maglogo: N pubinfo: dt: Oct2015 vid: 73 iid: 4 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 109445225 109445225 NLM26253362 10.1016/j.jaad.2015.06.021 NLM26253362 109445225 ppf: 691 ppct: 8 formats: tig: atl: Pathophysiology of pyoderma gangrenosum (PG): an updated review. aug: au: Braswell, Sara F. Kostopoulos, Tassia C. Ortega-Loayza, Alex G. affil: Department of Dermatology, Virginia Commonwealth University, Richmond, Virginia sug: subj: Cytokines Metabolism Immunosuppressive Agents Therapeutic Use Pyoderma Gangrenosum Physiopathology Genetic Screening Risk Assessment Disease Progression Immunohistochemistry Early Diagnosis Female Male Pyoderma Gangrenosum Drug Therapy Pyoderma Gangrenosum Biopsy, Needle Prognosis Treatment Outcomes Female Male ab: Pyoderma gangrenosum is a challenging skin condition to identify and treat because of its multifactorial pathogenesis. It is a rare cutaneous manifestation diagnosed clinically by exclusion of infection, neoplasia, thrombophilia, and other inflammatory conditions. Pathogenetic and treatment studies are scarce. Abnormalities in the function of inflammatory cytokines, the immune system, and neutrophils combined with specific genetic mutations predispose patients to develop this complex disease process. Early recognition of patients at risk for pyoderma gangrenosum, the necessity to improve its early diagnosis, and the future outlook of targeted and personalized therapies relies on the improved comprehension of the complex pathogenesis of pyoderma gangrenosum. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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