Posterior Cingulate Lactate as a Metabolic Biomarker in Amnestic Mild Cognitive Impairment.
Mitochondrial dysfunction represents a central factor within the pathogenesis of the Alzheimer's disease (AD) spectrum. We hypothesized that in vivo measurements of lactate (lac), a by-product of glycolysis, would correlate with functional impairment and measures of brain health in a cohort of 15 am...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 14 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
8/31/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109471170&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109471170 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/31/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109471170 109471170 NLM26417597 10.1155/2015/610605 NLM26417597 PMC4568343 109471170 ppf: 1 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Posterior Cingulate Lactate as a Metabolic Biomarker in Amnestic Mild Cognitive Impairment. aug: au: Weaver, Kurt E. Richards, Todd L. Logsdon, Rebecca G. McGough, Ellen L. Minoshima, Satoshi Aylward, Elizabeth H. Kleinhans, Natalia M. Grabowski, Thomas J. McCurry, Susan M. Teri, Linda affil: Department of Radiology, University of Washington, P.O. Box 357115, Seattle, WA 98195, USA sug: ab: Mitochondrial dysfunction represents a central factor within the pathogenesis of the Alzheimer's disease (AD) spectrum. We hypothesized that in vivo measurements of lactate (lac), a by-product of glycolysis, would correlate with functional impairment and measures of brain health in a cohort of 15 amnestic mild cognitive impairment (aMCI) individuals. Lac was quantified from the precuneus/posterior cingulate (PPC) using 2-dimensional J-resolved magnetic resonance spectroscopy (MRS). Additionally, standard behavioral and imaging markers of aMCI disease progression were acquired. PPC lac was negatively correlated with performance on the Wechsler logical memory tests and on the minimental state examination even after accounting for gray matter, cerebral spinal fluid volume, and age. No such relationships were observed between lac and performance on nonmemory tests. Significant negative relationships were also noted between PPC lac and hippocampal volume and PPC functional connectivity. Together, these results reveal that aMCI individuals with a greater disease progression have increased concentrations of PPC lac. Because lac is upregulated as a compensatory response to mitochondrial impairment, we propose that J-resolved MRS of lac is a noninvasive, surrogate biomarker of impaired metabolic function and would provide a useful means of tracking mitochondrial function during therapeutic trials targeting brain metabolism. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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