Hyper-connectivity of the thalamus during early stages following mild traumatic brain injury.
The thalamo-cortical resting state functional connectivity of seven sub-thalamic regions were examined in a prospectively recruited population of 77 acute mild TBI (mTBI) patients within the first 10 days (mean 6 ± 3 days) of injury and 35 neurologically intact control subjects using the Oxford thal...
| Publicado en: | Brain Imaging & Behavior Vol. 9; no. 3; pp. 550 - 564 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109542500&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109542500 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Sep2015 vid: 9 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109542500 109542500 NLM26153468 109542500 10.1007/s11682-015-9424-2 NLM26153468 PMC4577461 109542500 ppf: 550 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Hyper-connectivity of the thalamus during early stages following mild traumatic brain injury. aug: au: Sours, Chandler George, Elijah Zhuo, Jiachen Roys, Steven Gullapalli, Rao George, Elijah O Gullapalli, Rao P affil: Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA sug: subj: Thalamus Physiopathology Brain Injuries Physiopathology Adult Proton Magnetic Resonance Spectroscopy Time Factors Cognition Female Relaxation Maps Neural Pathways Physiopathology Acute Disease Neuropsychological Tests Magnetic Resonance Imaging Male Brain Injuries Psychosocial Factors Brain Mapping Prospective Studies Funding Source Clinical Assessment Tools Human Adult: 19-44 years Female Male ab: The thalamo-cortical resting state functional connectivity of seven sub-thalamic regions were examined in a prospectively recruited population of 77 acute mild TBI (mTBI) patients within the first 10 days (mean 6 ± 3 days) of injury and 35 neurologically intact control subjects using the Oxford thalamic connectivity atlas. Neuropsychological assessments were conducted using the Automated Neuropsychological Assessment Metrics (ANAM). A subset of participants received a magentic resonance spectroscopy (MRS) exam to determine metabolite concentrations in the thalamus and the posterior cingulate cortex. Results show that patients performed worse than the control group on various subtests of ANAM and the weighted throughput score, suggesting reduced cognitive performance at this early stage of injury. Both voxel and region of interest based analysis of the resting state fMRI data demonstrated that acute mTBI patients have increased functional connectivity between the various sub-thalamic regions and cortical regions associated with sensory processing and the default mode network (DMN). In addition, a significant reduction in NAA/Cr was observed in the thalamus in the mTBI patients. Furthermore, an increase in Cho/Cr ratio specific to mTBI patients with self-reported sensory symptoms was observed compared to those without self-reported sensory symptoms. These results provide novel insights into the neural mechanisms of the brain state related to internal rumination and arousal, which have implications for new interventions for mTBI patients with persistent symptoms. Furthermore, an understanding of heightened sensitivity to sensory related inputs during early stages of injury may facilitate enhanced prediction of safe return to work. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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