The suppression of brain activation in post-deployment military personnel with posttraumatic stress symptoms.
Previous research using cognitive paradigms has found task-related activation that includes prefrontal brain structures and that is attenuated in association with posttraumatic stress symptoms (PTSS). The present investigation used a cognitive control paradigm, the Arrows Task, to study subjects who...
| Publicado en: | Brain Imaging & Behavior Vol. 9; no. 3; pp. 513 - 527 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109542509&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109542509 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Sep2015 vid: 9 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109542509 109542509 NLM25875014 109542509 10.1007/s11682-015-9376-6 NLM25875014 109542509 ppf: 513 ppct: 14 formats: fmt: @attributes: type: P tig: atl: The suppression of brain activation in post-deployment military personnel with posttraumatic stress symptoms. aug: au: Scheibel, Randall Pastorek, Nicholas Troyanskaya, Maya Kennedy, Jan Steinberg, Joel Newsome, Mary Lin, Xiaodi Levin, Harvey Scheibel, Randall S Pastorek, Nicholas J Kennedy, Jan E Steinberg, Joel L Newsome, Mary R Levin, Harvey S affil: General Dynamics Information Technology contractor for the Defense and Veterans Brain Injury Center, San Antonio Military Medical Center, Fort Sam Houston USA sug: subj: Brain Physiopathology Military Personnel Psychosocial Factors Stress Disorders, Post-Traumatic Physiopathology Executive Function Male Magnetic Resonance Imaging Female Severity of Illness Indices Stress Disorders, Post-Traumatic Drug Therapy Adult Brain Mapping Physical Stimulation Visual Perception Physiology Neuropsychological Tests Time Factors Funding Source Checklists Human Adult: 19-44 years Male Female ab: Previous research using cognitive paradigms has found task-related activation that includes prefrontal brain structures and that is attenuated in association with posttraumatic stress symptoms (PTSS). The present investigation used a cognitive control paradigm, the Arrows Task, to study subjects who had not sustained a traumatic brain injury during deployment and who had a wide range of scores on the Posttraumatic Stress Disorder Checklist (PCL). During the Arrows Task there was no significant activation within the full sample of 15 subjects, but deactivation was found within areas that are likely to be involved in cognitive control, including the dorsal anterior cingulate gyrus and parietal cortex. Exploratory analyses were also conducted to compare subjects with relatively high PTSS (HIGH PTSS, n = 7) to those with lower severity or no symptoms (LOW PTSS, n = 8). LOW PTSS subjects exhibited activation in nonfrontal brain areas and their activation was greater relative to the HIGH PTSS subjects. In contrast, the HIGH PTSS group had extensive deactivation and there was a negative relationship between activation and PCL scores within subcortical structures, the cerebellum, and higher-order cortical association areas. For the HIGH PTSS group there was also a positive relationship between PCL scores and activation within basic sensory and motor areas, as well as structures thought to have a role in emotion and the regulation of internal bodily states. These findings are consistent with widespread neural dysfunction in subjects with greater PTSS, including changes similar to those reported to occur with acute stress and elevated noradrenergic activity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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