Retrospective comparison of gradient recalled echo R2* and spin-echo R2 magnetic resonance analysis methods for estimating liver iron content in children and adolescents.
Background: Serial surveillance of liver iron concentration (LIC) provides guidance for chelation therapy in patients with iron overload. The diagnosis of iron overload traditionally relies on core liver biopsy, which is limited by invasiveness, sampling error, cost and general poor acceptance by pe...
| Publicado en: | Pediatric Radiology Vol. 45; no. 11; pp. 1629 - 1635 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109556331&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109556331 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Oct2015 vid: 45 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109556331 109556331 NLM26008870 109556331 10.1007/s00247-015-3378-9 NLM26008870 109556331 ppf: 1629 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Retrospective comparison of gradient recalled echo R2* and spin-echo R2 magnetic resonance analysis methods for estimating liver iron content in children and adolescents. aug: au: Serai, Suraj Fleck, Robert Quinn, Charles Zhang, Bin Podberesky, Daniel Serai, Suraj D Fleck, Robert J Quinn, Charles T Podberesky, Daniel J affil: Department of Radiology, MLC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. Cincinnati 45229 USA sug: subj: Liver Metabolism Magnetic Resonance Spectroscopy Methods Liver Anatomy and Histology Magnetic Resonance Imaging Methods Liver Diseases Metabolism Iron Overload Metabolism Liver Diseases Diagnosis Female Male Retrospective Design Adolescence Molecular Imaging Methods Young Adult Reproducibility of Results Image Enhancement Methods Iron Overload Diagnosis Algorithms Child, Preschool Human Child Sensitivity and Specificity Image Interpretation, Computer Assisted Methods Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adolescent: 13-18 years Child, Preschool: 2-5 years Child: 6-12 years Female Male ab: Background: Serial surveillance of liver iron concentration (LIC) provides guidance for chelation therapy in patients with iron overload. The diagnosis of iron overload traditionally relies on core liver biopsy, which is limited by invasiveness, sampling error, cost and general poor acceptance by pediatric patients and parents. Thus noninvasive diagnostic methods such as MRI are highly attractive for quantification of liver iron concentration.Objective: To compare two MRI-based methods for liver iron quantification in children.Materials and Methods: 64 studies on 48 children and young adults (age range 4-21 years) were examined by gradient recalled echo (GRE) R2* and spin-echo R2 MRI at 1.5T to evaluate liver iron concentration. Scatter plots and Bland-Altman difference plots were generated to display and assess the relationship between the methods.Results: With the protocols used in this investigation, Bland-Altman agreement between the methods is best when LIC is <20 mg/g dry tissue. Scatter plots show that all values with LIC <20 mg/g dry tissue fall within the 95% prediction limits.Conclusion: Liver iron concentration as determined by the R2* and R2 MR methods is statistically comparable, with no statistical difference between these methods for LIC <20 mg/g. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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