An interactive web application for the dissemination of human systems immunology data.
Background: Systems immunology approaches have proven invaluable in translational research settings. The current rate at which large-scale datasets are generated presents unique challenges and opportunities. Mining aggregates of these datasets could accelerate the pace of discovery, but new solution...
| Publicado en: | Journal of Translational Medicine Vol. 13; no. 1; pp. 196 - 197 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109583371&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109583371 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14795876 1CW3 jtl: Journal of Translational Medicine issn: 14795876 maglogo: N pubinfo: dt: 2015 vid: 13 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 109583371 NLM26088622 2013058642 10.1186/s12967-015-0541-x NLM26088622 PMC4474328 109583371 ppf: 196 ppct: 1 formats: tig: atl: An interactive web application for the dissemination of human systems immunology data. aug: au: Speake, Cate Presnell, Scott Domico, Kelly Zeitner, Brad Bjork, Anna Anderson, David Mason, Michael J Whalen, Elizabeth Vargas, Olivia Popov, Dimitry Rinchai, Darawan Jourde-Chiche, Noemie Chiche, Laurent Quinn, Charlie Chaussabel, Damien sug: ab: Background: Systems immunology approaches have proven invaluable in translational research settings. The current rate at which large-scale datasets are generated presents unique challenges and opportunities. Mining aggregates of these datasets could accelerate the pace of discovery, but new solutions are needed to integrate the heterogeneous data types with the contextual information that is necessary for interpretation. In addition, enabling tools and technologies facilitating investigators' interaction with large-scale datasets must be developed in order to promote insight and foster knowledge discovery.Methods: State of the art application programming was employed to develop an interactive web application for browsing and visualizing large and complex datasets. A collection of human immune transcriptome datasets were loaded alongside contextual information about the samples.Results: We provide a resource enabling interactive query and navigation of transcriptome datasets relevant to human immunology research. Detailed information about studies and samples are displayed dynamically; if desired the associated data can be downloaded. Custom interactive visualizations of the data can be shared via email or social media. This application can be used to browse context-rich systems-scale data within and across systems immunology studies. This resource is publicly available online at [Gene Expression Browser Landing Page ( https://gxb.benaroyaresearch.org/dm3/landing.gsp )]. The source code is also available openly [Gene Expression Browser Source Code ( https://github.com/BenaroyaResearch/gxbrowser )].Conclusions: We have developed a data browsing and visualization application capable of navigating increasingly large and complex datasets generated in the context of immunological studies. This intuitive tool ensures that, whether taken individually or as a whole, such datasets generated at great effort and expense remain interpretable and a ready source of insight for years to come. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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