Caveat of measuring perfusion indexes using intravoxel incoherent motion magnetic resonance imaging in the human brain.
Objectives: To numerically and experimentally investigate the robustness of intravoxel incoherent motion (IVIM) magnetic resonance imaging in measuring perfusion indexes in the human brain.Methods: Eighteen healthy volunteers were imaged on a 3 T clinical system. Data of IVIM imaging (12 b-values ra...
| Publicado en: | European Radiology Vol. 25; no. 8; pp. 2485 - 2493 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109594947&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109594947 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2015 vid: 25 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109594947 103687092 NLM25693668 2013091315 10.1007/s00330-015-3655-x NLM25693668 PMC4495260 109594947 ppf: 2485 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Caveat of measuring perfusion indexes using intravoxel incoherent motion magnetic resonance imaging in the human brain. aug: au: Wu, Wen-Chau Chen, Ya-Fang Tseng, Han-Min Yang, Shun-Chung My, Pei-Chi sug: subj: Brain Blood Supply Cerebrovascular Circulation Physiology Research Subjects Gray Matter Blood Supply Human Female Male Magnetic Resonance Imaging Methods Motion Sensitivity and Specificity Models, Theoretical Prospective Studies Young Adult Adult Pilot Studies Validation Studies Comparative Studies Evaluation Research Multicenter Studies Barthel Index Scales Adult: 19-44 years Female Male ab: Objectives: To numerically and experimentally investigate the robustness of intravoxel incoherent motion (IVIM) magnetic resonance imaging in measuring perfusion indexes in the human brain.Methods: Eighteen healthy volunteers were imaged on a 3 T clinical system. Data of IVIM imaging (12 b-values ranging from 0 to 1000 s/mm(2), 12 repetitions) were fitted with a bi-exponential model to extract blood volume fraction (f) and pseudo-diffusion coefficient (D*). The robustness of measurement was assessed by bootstrapping. Dynamic susceptibility contrast (DSC) imaging and arterial spin-labelling (ASL) imaging were performed for cross-modal comparison. Numerical simulations were performed to assess the accuracy and precision of f and D* estimates at varied signal-to-noise ratio (SNRb1000).Results: Based on our experimental setting (SNRb1000 ~ 30), the average error/variability is ~5 %/25 % for f and ~100 %/30 % for D* in gray matter, and ~10 %/50 % for f and ~300 %/60 % for D* in white matter. Correlation was found between f and DSC-derived cerebral blood volume in gray matter (r = 0.29 - 0.48 across subjects, p < 10(-5)), but not in white matter. No correlation was found between f-D* product and ASL-derived cerebral blood flow.Conclusions: f may provide noninvasive measurement of cerebral blood volume, particularly in gray matter. D* has limited robustness and should be interpreted with caution.Key Points: • A minimum SNR b1000 of 30 is recommended for reliable IVIM imaging. • f may provide noninvasive measurement of cerebral blood volume. • f correlates with CBV DSC in gray matter. • There is no correlation between fD* and CBF ASL . • D* has limited robustness and should be interpreted with caution. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|