Virtual iron concentration imaging based on dual-energy CT for noninvasive quantification and grading of liver iron content: An iron overload rabbit model study.
Objectives: To assess the accuracy of liver iron content (LIC) quantification and grading ability associated with clinical LIC stratification using virtual iron concentration (VIC) imaging on dual-energy CT (DECT) in an iron overload rabbit model.Methods: Fifty-one rabbits were prepared as iron-load...
| Published in: | European Radiology Vol. 25; no. 9; pp. 2657 - 2665 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Sep2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109616226&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109616226 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2015 vid: 25 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109616226 NLM25773943 2013116105 10.1007/s00330-015-3693-4 NLM25773943 109616226 ppf: 2657 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Virtual iron concentration imaging based on dual-energy CT for noninvasive quantification and grading of liver iron content: An iron overload rabbit model study. aug: au: Luo, Xian Fu Yang, Yi Yan, Jing Xie, Xue Qian Zhang, Huan Chai, Wei Min Wang, Li Schmidt, Bernhard Yan, Fu Hua sug: ab: Objectives: To assess the accuracy of liver iron content (LIC) quantification and grading ability associated with clinical LIC stratification using virtual iron concentration (VIC) imaging on dual-energy CT (DECT) in an iron overload rabbit model.Methods: Fifty-one rabbits were prepared as iron-loaded models by intravenous injection of iron dextran. DECT was performed at 80 and 140 kVp. VIC images were derived from an iron-specific algorithm. Postmortem LIC assessments were conducted on an inductively coupled plasma (ICP) spectrometer. Correlation between VIC and LIC was analyzed. VIC were stratified according to the corresponding clinical LIC thresholds of 1.8, 3.2, 7.0, and 15.0 mg Fe/g. Diagnostic performance of stratification was evaluated by receiver operating characteristic analysis.Results: VIC linearly correlated with LIC (r = 0.977, P < 0.01). No significant difference was observed between VIC-derived LICs and ICP (P > 0.05). For the four clinical LIC thresholds, the corresponding cutoff values of VIC were 19.6, 25.3, 36.9, and 61.5 HU, respectively. The highest sensitivity (100%) and specificity (100 %) were achieved at the threshold of 15.0 mg Fe/g.Conclusions: Virtual iron concentration imaging on DECT showed potential ability to accurately quantify and stratify hepatic iron accumulation in the iron overload rabbit model.Key Points: • Virtual iron concentration (VIC) linearly correlates with liver iron content (LIC). • VIC accurately quantifies LIC. • VIC accurately grades LIC based on clinical LIC stratification. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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