Can the height-independent Pottel eGFR equation be used as a screening tool for chronic kidney disease in children?
Unlabelled: Determination of plasma creatinine (Pcr) should be associated to an estimation of glomerular filtration rate (eGFR). Pottel et al. established a height-independent equation, eGFR = 107.3/(Pcr/Q) where Q is the median of Pcr (Pottel-Belgium). The aims were to 1) determine a local height-i...
| Publicado en: | European Journal of Pediatrics Vol. 174; no. 9; pp. 1225 - 1236 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109623537&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109623537 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03406199 CR1 jtl: European Journal of Pediatrics issn: 03406199 maglogo: N pubinfo: dt: Sep2015 vid: 174 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109623537 108951664 NLM25846696 2013131880 10.1007/s00431-015-2523-7 NLM25846696 109623537 ppf: 1225 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Can the height-independent Pottel eGFR equation be used as a screening tool for chronic kidney disease in children? aug: au: De Souza, Vandréa Pottel, Hans Hoste, Liesbeth Dolomanova, Olga Cartier, Regine Selistre, Luciano Ranchin, Bruno Hadj-Aïssa, Aoumeur Lemoine, Sandrine Cochat, Pierre Dubourg, Laurence sug: subj: Health Screening Creatinine Blood Renal Insufficiency, Chronic Physiopathology Glomerular Filtration Rate Physiology Prospective Studies Child, Preschool Infant Kidney Physiopathology Retrospective Design Renal Insufficiency, Chronic Epidemiology Child Renal Insufficiency, Chronic Diagnosis Belgium Male Adolescence Female Arthritis Impact Measurement Scales Questionnaires Child, Preschool: 2-5 years Infant: 1-23 months Child: 6-12 years Adolescent: 13-18 years Male Female ab: Unlabelled: Determination of plasma creatinine (Pcr) should be associated to an estimation of glomerular filtration rate (eGFR). Pottel et al. established a height-independent equation, eGFR = 107.3/(Pcr/Q) where Q is the median of Pcr (Pottel-Belgium). The aims were to 1) determine a local height-independent equation (Pottel-Lyon), 2) evaluate the performance of these equations compared to the Schwartz 2009 and Schwartz-Lyon equations, and 3) evaluate the height-independent equations in laboratory routine. Therefore, 1) all first pediatric Pcr determination (December 2009-June 2011) were collected, and median of Pcr was determined for each 1-year age interval (Q-Lyon), 2) GFR was measured (mGFR) in 359 children (438 measures) and compared to eGFR, and 3) all first Pcr determination (January 2012-June 2013) were used to calculate eGFR with the Pottel-Lyon and the Pottel-Belgium equations. Pcr was determined by an IDMS-standardized enzymatic assay. In the population with a mGFR, the Pottel-Lyon and the Schwartz-Lyon showed the best performance (bias, P10 and P30). However, the performance in identifying patients with a mGFR < 75 mL/min/1.73 m(2) was similar for all the studied equations.Conclusion: The performance of the height-independent and dependent equations to identify mild renal dysfunction is similar. The height-independent Pottel equation could be proposed as an excellent screening tool for kidney disease when height information is not available. "What Is Known: " • Determination of plasma creatinine in children is rarely associated to an estimation of glomerular filtration rate due to the lack of height information. • Pottel et al. developed a height-independent equation (eGFR = 107.3/(Pcr/Q) where Q is the median of Pcr for each age class. "What Is New: " • The performance of the height-independent (Pottel) or height-dependent (Schwartz) equations is similar to identify renal dysfunction (GFR < 75 mL/min/1.73 m (2) ) in children. • The height-independent Pottel equation could be an excellent screening tool for kidney disease in a general pediatric laboratory when height information is not available. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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