Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis.
Introduction: Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability...
| Publicado en: | BioMed Research International Vol. 2015; pp. 569123 - 569124 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
1/1/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109625040&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109625040 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/1/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109625040 109625040 NLM26295042 2013133469 10.1155/2015/569123 NLM26295042 PMC4532805 109625040 ppf: 569123 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis. aug: au: Bonnier, Guillaume Roche, Alexis Romascano, David Simioni, Samanta Meskaldji, Djalel Eddine Rotzinger, David Lin, Ying-Chia Menegaz, Gloria Schluep, Myriam Du Pasquier, Renaud Sumpf, Tilman Johannes Frahm, Jens Thiran, Jean-Philippe Krueger, Gunnar Granziera, Cristina sug: ab: Introduction: Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability.Methods: 36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2(*) relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linear model assessed the contribution of lesion groups to clinical performances.Results: Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with general disability (Adj-R (2) = 0.6; P = 0.0005), executive function (Adj-R (2) = 0.5; P = 0.004), verbal memory (Adj-R (2) = 0.4; P = 0.02), and attention (Adj-R (2) = 0.5; P = 0.002).Conclusion: Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that neurodegeneration is the major determinant of patients' disability and cognitive dysfunction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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