Neurological Outcomes After Presumed Childhood Encephalitis.
Objective: To evaluate factors during acute presumed childhood encephalitis that are associated with development of long-term neurological sequelae.Methods: A total of 217 patients from Rady Children's Hospital San Diego with suspected encephalitis who met criteria for the California Encephalitis Pr...
| Published in: | Pediatric Neurology Vol. 53; no. 3; pp. 200 - 207 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Elsevier B.V.
Sep2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109632507&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109632507 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08878994 JNS jtl: Pediatric Neurology issn: 08878994 maglogo: N pubinfo: dt: Sep2015 vid: 53 iid: 3 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 109632507 NLM26220354 2013144730 10.1016/j.pediatrneurol.2015.05.017 NLM26220354 109632507 ppf: 200 ppct: 7 formats: tig: atl: Neurological Outcomes After Presumed Childhood Encephalitis. aug: au: Rismanchi, Neggy Gold, Jeffrey J Sattar, Shifteh Glaser, Carol Sheriff, Heather Proudfoot, James Mower, Andrew Nespeca, Mark Crawford, John R Wang, Sonya G sug: ab: Objective: To evaluate factors during acute presumed childhood encephalitis that are associated with development of long-term neurological sequelae.Methods: A total of 217 patients from Rady Children's Hospital San Diego with suspected encephalitis who met criteria for the California Encephalitis Project were identified. A cohort of 99 patients (40 females, 59 males, age 2 months-17 years) without preexisting neurological conditions, including prior seizures or abnormal brain magnetic resonance imaging scans was studied. Mean duration of follow-up was 29 months. Factors that had a relationship with the development of neurological sequelae (defined as developmental delay, learning difficulties, behavioral problems, or focal neurological findings) after acute encephalitis were identified.Results: Neurological sequelae at follow-up was associated with younger age (6.56 versus 9.22 years) at presentation (P = 0.04) as well as an initial presenting sign of seizure (P = 0.03). Duration of hospital stay (median of 7 versus 15.5 days; P = 0.02) was associated with neurological sequelae. Of the patients with neurological sequelae, a longer hospital stay was associated with patients of an older age (P = 0.04). Abnormalities on neuroimaging (P = 1.00) or spinal fluid analysis (P = 1.00) were not uniquely associated with neurological sequelae. Children who were readmitted after their acute illness (P = 0.04) were more likely to develop neurological sequelae. There was a strong relationship between the patients who later developed epilepsy and those who developed neurological sequelae (P = 0.02).Significance: Limited data are available on the long-term neurological outcomes of childhood encephalitis. Almost half of our patients were found to have neurological sequelae at follow-up, indicating the importance of earlier therapies to improve neurological outcome. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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