Depth of bacterial invasion in resected intestinal tissue predicts mortality in surgical necrotizing enterocolitis.
Objective:Up to a third of all infants who develop necrotizing enterocolitis (NEC) require surgical resection of necrotic bowel. We hypothesized that the histopathological findings in surgically resected bowel can predict the clinical outcome of these infants.Study Design:We reviewed the medical rec...
| Publicado en: | Journal of Perinatology Vol. 35; no. 9; pp. 755 - 763 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109636310&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109636310 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: Sep2015 vid: 35 iid: 9 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 109636310 109110049 10.1038/jp.2015.51 NLM25950918 109636310 ppf: 755 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Depth of bacterial invasion in resected intestinal tissue predicts mortality in surgical necrotizing enterocolitis. aug: au: Remon, J I Amin, S C Mehendale, S R Rao, R Luciano, A A Garzon, S A Maheshwari, A affil: Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA sug: ab: Objective:Up to a third of all infants who develop necrotizing enterocolitis (NEC) require surgical resection of necrotic bowel. We hypothesized that the histopathological findings in surgically resected bowel can predict the clinical outcome of these infants.Study Design:We reviewed the medical records and archived pathology specimens from all patients who underwent bowel resection/autopsy for NEC at a regional referral center over a 10-year period. Pathology specimens were graded for the depth and severity of necrosis, inflammation, bacteria invasion and pneumatosis, and histopathological findings were correlated with clinical outcomes.Result:We performed clinico-pathological analysis on 33 infants with confirmed NEC, of which 18 (54.5%) died. Depth of bacterial invasion in resected intestinal tissue predicted death from NEC (odds ratio 5.39 per unit change in the depth of bacterial invasion, 95% confidence interval 1.33 to 21.73). The presence of transmural necrosis and bacteria in the surgical margins of resected bowel was also associated with increased mortality.Conclusion:Depth of bacterial invasion in resected intestinal tissue predicts mortality in surgical NEC. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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