Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis.
Objectives: To compare systematically quantitative MRI, MR spectroscopy (MRS), and different histological methods for liver fat quantification in order to identify possible incongruities.Methods: Fifty-nine consecutive patients with liver disorders were examined on a 3 T MRI system. Quantitative MRI...
| Published in: | European Radiology Vol. 25; no. 10; pp. 2869 - 2880 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Oct2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109645559&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109645559 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2015 vid: 25 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109645559 NLM25903702 2013163932 10.1007/s00330-015-3703-6 NLM25903702 109645559 ppf: 2869 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis. aug: au: Kukuk, Guido M Hittatiya, Kanishka Sprinkart, Alois M Eggers, Holger Gieseke, Jürgen Block, Wolfgang Moeller, Philipp Willinek, Winfried A Spengler, Ulrich Trebicka, Jonel Fischer, Hans-Peter Schild, Hans H Träber, Frank sug: subj: Fatty Liver Pathology Prospective Studies Epithelial Cells Pathology Middle Age Histological Techniques Aged Young Adult Adolescence Adult Female Male Magnetic Resonance Imaging Methods Human Magnetic Resonance Spectroscopy Methods Software Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Middle Aged: 45-64 years Aged: 65+ years Adolescent: 13-18 years Adult: 19-44 years Female Male ab: Objectives: To compare systematically quantitative MRI, MR spectroscopy (MRS), and different histological methods for liver fat quantification in order to identify possible incongruities.Methods: Fifty-nine consecutive patients with liver disorders were examined on a 3 T MRI system. Quantitative MRI was performed using a dual- and a six-echo variant of the modified Dixon (mDixon) sequence, calculating proton density fat fraction (PDFF) maps, in addition to single-voxel MRS. Histological fat quantification included estimation of the percentage of hepatocytes containing fat vesicles as well as semi-automatic quantification (qHisto) using tissue quantification software.Results: In 33 of 59 patients, the hepatic fat fraction was >5% as determined by MRS (maximum 45%, mean 17%). Dual-echo mDixon yielded systematically lower PDFF values than six-echo mDixon (mean difference 1.0%; P < 0.001). Six-echo mDixon correlated excellently with MRS, qHisto, and the estimated percentage of hepatocytes containing fat vesicles (R = 0.984, 0.967, 0.941, respectively, all P < 0.001). Mean values obtained by the estimated percentage of hepatocytes containing fat were higher by a factor of 2.5 in comparison to qHisto. Six-echo mDixon and MRS showed the best agreement with values obtained by qHisto.Conclusions: Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results and are therefore most appropriate for reliable quantification of liver fat.Key Points: • Six-echo mDixon correlates excellently with MRS, qHisto, and the estimated percentage of fat-containing hepatocytes. • Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results. • Dual-echo mDixon yields systematically lower PDFF values than six-echo mDixon. • The percentage of fat-containing hepatocytes is 2.5-fold higher than fat fraction determined by qHisto. • Performance characteristics and systematic differences of the various methods should be considered. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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