Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study.
Introduction: MAPK genes are activated by a variety of factors related to growth factors, hormones, and environmental stress.Methods: We evaluated associations between 13 MAPK genes and survival among 1,187 nonHispanic White and 1,155 Hispanic/Native American (NA) women diagnosed with breast cancer....
| Publicado en: | Cancer Causes & Control Vol. 25; no. 9; pp. 1211 - 1226 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109677652&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109677652 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Sep2014 vid: 25 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109677652 NLM24993294 2012709849 10.1007/s10552-014-0426-y NLM24993294 PMC4156917 109677652 ppf: 1211 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study. aug: au: Slattery, Martha L Hines, Lisa H Lundgreen, Abbie Baumgartner, Kathy B Wolff, Roger K Stern, Mariana C John, Esther M sug: ab: Introduction: MAPK genes are activated by a variety of factors related to growth factors, hormones, and environmental stress.Methods: We evaluated associations between 13 MAPK genes and survival among 1,187 nonHispanic White and 1,155 Hispanic/Native American (NA) women diagnosed with breast cancer. We assessed the influence of diet, lifestyle, and genetic ancestry on these associations. Percent NA ancestry was determined from 104 Ancestry Informative Markers. Adaptive rank truncation product (ARTP) was used to determine gene and pathway significance.Results: Associations were predominantly observed among women with lower NA ancestry. Specifically, the mitogen-activated protein kinases (MAPK) pathway was associated with all-cause mortality (P ARTP = 0.02), but not with breast cancer-specific mortality (P ARTP = 0.10). However, MAP2K1 and MAP3K9 were associated with both breast cancer-specific and all-cause mortality. MAPK12 (P ARTP = 0.05) was only associated with breast cancer-specific mortality, and MAP3K1 (P ARTP = 0.02) and MAPK1 (P ARTP = 0.05) were only associated with all-cause mortality. Among women with higher NA ancestry, MAP3K2 was significantly associated with all-cause mortality (P ARTP = 0.04). Several diet and lifestyle factors, including alcohol consumption, caloric intake, dietary folate, and cigarette smoking, significantly modified the associations with MAPK genes and all-cause mortality.Conclusions: Our study supports an association between MAPK genes and survival after diagnosis with breast cancer, especially among women with low NA ancestry. The interaction between genetic variation in the MAPK pathway with diet and lifestyle factors for all women supports the important role of these factors for breast cancer survivorship. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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