The use of a second biopsy from the gastric body for the detection of Helicobacter pylori using rapid urease test.
Introduction: The use of an additional biopsy from the gastric body may help improve the detection of Helicobacter pylori during endoscopy. This study aimed to determine whether such an additional biopsy is necessary in routine rapid urease test (RUT), and whether acid suppression and antibiotic the...
| Publicado en: | Singapore Medical Journal Vol. 55; no. 12; pp. 644 - 648 |
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| Autores principales: | , , , , , |
| Formato: | historical material research Journal Article |
| Publicado: |
Singapore Medical Association
Dec2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109695150&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109695150 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00375675 1D3F jtl: Singapore Medical Journal issn: 00375675 maglogo: N pubinfo: dt: Dec2014 vid: 55 iid: 12 pid: 24840 pub: Singapore Medical Association artinfo: ui: 109695150 NLM25630318 2012883781 10.11622/smedj.2014178 NLM25630318 PMC4292002 109695150 ppf: 644 ppct: 4 formats: tig: atl: The use of a second biopsy from the gastric body for the detection of Helicobacter pylori using rapid urease test. aug: au: Wong, A S Ching, S S Long, A S Wong, Andrew Ching, Siok Siong Long, Ai Sha affil: Department of Surgery, Changi General Hospital, 2 Simei Street 3, Singapore 529889 sug: ab: Introduction: The use of an additional biopsy from the gastric body may help improve the detection of Helicobacter pylori during endoscopy. This study aimed to determine whether such an additional biopsy is necessary in routine rapid urease test (RUT), and whether acid suppression and antibiotic therapy affect RUT results.Methods: Patients recruited had two gastric mucosal biopsies taken - one from the gastric antrum and the other from the gastric body. Each biopsy was placed into separate RUT kits. Information on previous or current use of proton-pump inhibitors, H2 receptor antagonist, bismuth and antibiotics was obtained. Patients on any of those drugs one week prior to endoscopy were considered to have a positive drug history (PDH).Results: Of the 400 patients recruited, 311 had negative RUTs and 89 had at least one positive RUT. Between the PDH and negative drug history (NDH) groups, there was a significant difference in the distribution of the location of the biopsies that yielded positive RUTs (p = 0.023). The NDH group had a higher proportion of patients who had positive RUTs for both locations, whereas the PDH group had a higher proportion of patients who had positive RUTs for only one location.Conclusion: As RUT results are significantly affected by the use of acid suppression and antibiotic therapies, biopsies for RUT should be taken from both the gastric antrum and body to minimise false negative results. pubtype: Academic Journal doctype: historical material research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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