Heterogeneity of neural mechanisms of response to pivotal response treatment.
We investigated the mechanisms by which Pivotal Response Treatment (PRT) improves social communication in a case series of 10 preschool-aged children with Autism Spectrum Disorder (ASD). Functional magnetic resonance imaging (fMRI) identified brain responses during a biological motion perception tas...
| Publicado en: | Brain Imaging & Behavior Vol. 9; no. 1; pp. 74 - 89 |
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| Autores principales: | , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Springer Nature
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109708625&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109708625 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Mar2015 vid: 9 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109708625 NLM25370452 2012934376 10.1007/s11682-014-9331-y NLM25370452 PMC4993028 109708625 ppf: 74 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Heterogeneity of neural mechanisms of response to pivotal response treatment. aug: au: Ventola, Pamela Yang, Daniel Y J Friedman, Hannah E Oosting, Devon Wolf, Julie Sukhodolsky, Denis G Pelphrey, Kevin A sug: ab: We investigated the mechanisms by which Pivotal Response Treatment (PRT) improves social communication in a case series of 10 preschool-aged children with Autism Spectrum Disorder (ASD). Functional magnetic resonance imaging (fMRI) identified brain responses during a biological motion perception task conducted prior to and following 16 weeks of PRT treatment. Overall, the neural systems supporting social perception in these 10 children were malleable through implementation of PRT; following treatment, neural responses were more similar to those of typically developing children (TD). However, at baseline, half of the children exhibited hypoactivation, relative to a group of TD children, in the right posterior superior temporal sulcus (pSTS), and half exhibited hyperactivation in this region. Strikingly, the groups exhibited differential neural responses to treatment: The five children who exhibited hypoactivation at baseline evidenced increased activation in components of the reward system including the ventral striatum and putamen. The five children who exhibited hyperactivation at baseline evidenced decreased activation in subcortical regions critical for regulating the flow of stimulation and conveying signals of salience to the cortex-the thalamus, amygdala, and hippocampus. Our results support further investigation into the differential effects of particular treatment strategies relative to specific neural targets. Identification of treatment strategies that address the patterns of neural vulnerability unique to each patient is consistent with the priority of creating individually tailored interventions customized to the behavioral and neural characteristics of a given person. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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