Cutaneous findings in hemophagocytic lymphohistiocytosis.
Background: Cutaneous findings associated with hemophagocytic lymphohistiocytosis (HLH) remain largely undescribed in the literature, yet are substantial and correlative with disease course.Objective: To catalog the clinical findings of cutaneous eruptions associated with HLH.Methods: We performed a...
| Publicado en: | Dermatology (10188665) Vol. 230; no. 3; pp. 234 - 244 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Karger AG
May2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109709625&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109709625 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188665 NIG jtl: Dermatology (10188665) issn: 10188665 maglogo: N pubinfo: dt: May2015 vid: 230 iid: 3 pid: 2485 pub: Karger AG artinfo: ui: 109709625 NLM25677716 2012937524 10.1159/000368552 NLM25677716 109709625 ppf: 234 ppct: 10 formats: tig: atl: Cutaneous findings in hemophagocytic lymphohistiocytosis. aug: au: Zerah, Michele L DeWitt, Christine A sug: ab: Background: Cutaneous findings associated with hemophagocytic lymphohistiocytosis (HLH) remain largely undescribed in the literature, yet are substantial and correlative with disease course.Objective: To catalog the clinical findings of cutaneous eruptions associated with HLH.Methods: We performed a retrospective chart review of patients meeting the criteria for HLH at two hospitals over 5 years. All patients meeting the criteria for HLH as defined by the HLH-2004 protocol were included.Results: Cutaneous lesions were categorized based on clinical presentations and histology. Lesions independent of immunocompromised state were observed, including pyoderma gangrenosum, panniculitis, morbilliform eruptions, Stevens-Johnson syndrome, atypical targetoid lesions and bullae. Histologic findings were non-specific.Conclusion: Cutaneous eruptions as a consequence of HLH are variable in presentation and identified as a diagnosis of exclusion. Findings are both primarily and secondarily induced by altered immunity. Further study is needed to allow better understanding of the immunopathogenesis involved. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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