Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies.
Purpose: Thyroid cancer has a higher incidence in women than in men, and it has been hypothesized that hormonal factors may explain such disparity. We performed a meta-analysis of observational prospective studies to investigate the association between menstrual and reproductive variables and exogen...
| Publicado en: | Cancer Causes & Control Vol. 26; no. 4; pp. 511 - 519 |
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| Autores principales: | , , , , , |
| Formato: | research review Journal Article |
| Publicado: |
Springer Nature
Apr2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109712260&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109712260 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Apr2015 vid: 26 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109712260 NLM25754110 2012943345 10.1007/s10552-015-0546-z NLM25754110 109712260 ppf: 511 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies. aug: au: Caini, Saverio Gibelli, Bianca Palli, Domenico Saieva, Calogero Ruscica, Massimilano Gandini, Sara sug: ab: Purpose: Thyroid cancer has a higher incidence in women than in men, and it has been hypothesized that hormonal factors may explain such disparity. We performed a meta-analysis of observational prospective studies to investigate the association between menstrual and reproductive variables and exogenous hormone use and the risk of thyroid cancer among women.Methods: We calculated summary relative risks and 95% confidence intervals (95% CI) using random effect models.Results: Overall, 5,434 thyroid cancer cases from twenty-four papers were included. Increasing age at first pregnancy/birth (SRR 1.56, 95% CI 1.01-2.42) and hysterectomy (SRR 1.43, 95% CI 1.15-1.78) were associated with thyroid cancer risk. Women that were in menopause at enrolment had a reduced thyroid cancer risk (SRR 0.79, 95% CI 0.62-1.01). No other menstrual, reproductive, and hormonal variable was associated with thyroid cancer risk.Conclusions: Menstrual and reproductive factors may play a role in the etiology of thyroid cancer, possibly through the mediation of estrogen receptors. pubtype: Academic Journal doctype: meta analysis research review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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