Diffusion-weighted perinatal postmortem magnetic resonance imaging as a marker of postmortem interval.
Objective: To evaluate perinatal body organ apparent diffusion coefficient (ADC) values at postmortem magnetic resonance imaging (PMMR) in order to evaluate postmortem changes.Methods: Postmortem diffusion-weighted imaging (DWI) of the thorax and abdomen were performed with diffusion gradient values...
| Publicado en: | European Radiology Vol. 25; no. 5; pp. 1399 - 1407 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109720217&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109720217 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2015 vid: 25 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109720217 NLM25519976 2012969014 10.1007/s00330-014-3525-y NLM25519976 PMC4392167 109720217 ppf: 1399 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Diffusion-weighted perinatal postmortem magnetic resonance imaging as a marker of postmortem interval. aug: au: Arthurs, Owen J Price, Gemma C Carmichael, David W Jones, Rod Norman, Wendy Taylor, Andrew M Sebire, Neil J sug: subj: Lung Pathology Postmortem Changes Kidney Pathology Liver Pathology Magnetic Resonance Imaging Methods Fetal Diseases Pathology Abnormalities Pathology Lung Anatomy and Histology Perinatal Death Male Retrospective Design Spleen Liver Anatomy and Histology Female Infant, Newborn Autopsy Infant Human Kidney Anatomy and Histology Validation Studies Comparative Studies Evaluation Research Multicenter Studies Infant, Newborn: birth-1 month Infant: 1-23 months Male Female ab: Objective: To evaluate perinatal body organ apparent diffusion coefficient (ADC) values at postmortem magnetic resonance imaging (PMMR) in order to evaluate postmortem changes.Methods: Postmortem diffusion-weighted imaging (DWI) of the thorax and abdomen were performed with diffusion gradient values b = 0, 500, and 1000 s/mm(2) on 15 foetal and childhood cases (mean 33.3 ± 7.8 weeks gestation) compared to 44 live infants (mean age 75.5 ± 53.4 days). Mean ADC values were calculated from regions of interest (ROIs) for the lungs, liver, spleen and renal cortex, compared to normative live infantile body ADC values of similar gestational age.Results: Mean ADC values were significantly lower in postmortem cases than in normal controls for liver (0.88 10(-3) mm(2)/s ± SD 0.39 vs. 1.13 ± 0.13; p < 0.05) and renal cortex (0.85 ± 0.26 vs. 1.19 ± 0.13; p < 0.05) but not spleen or muscle. Mean lung ADC values were significantly higher than normal controls (1.06 ± 0.18 vs. 0 ± 0; p < 0.001), and there was a significant correlation between postmortem interval and lung ADC (R(2) = 0.55).Conclusion: Lung PMMR ADC values are related to postmortem interval, making them a potential marker of time since death. Further research is needed to understand the organ-specific changes which occur in the postmortem period.Key Points: • Liver and spleen PM ADC values were lower than controls. • Lung ADC changes correlate with PM interval. • These findings may be useful in medicolegal cases. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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