Diffusion-weighted magnetic resonance imaging for prediction of insignificant prostate cancer in potential candidates for active surveillance.
Objectives: To investigate whether the apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) could help improve the prediction of insignificant prostate cancer in candidates for active surveillance (AS).Methods: Enrolled in this retrospective study were 287...
| Publicado en: | European Radiology Vol. 25; no. 6; pp. 1786 - 1793 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109732028&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109732028 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2015 vid: 25 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109732028 NLM25636416 2012995381 10.1007/s00330-014-3566-2 NLM25636416 109732028 ppf: 1786 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Diffusion-weighted magnetic resonance imaging for prediction of insignificant prostate cancer in potential candidates for active surveillance. aug: au: Kim, Tae Heon Jeong, Jae Yong Lee, Sin Woo Kim, Chan Kyo Park, Byung Kwan Sung, Hyun Hwan Jeon, Hwang Gyun Jeong, Byong Chang Seo, Seong Il Lee, Hyun Moo Choi, Han Yong Jeon, Seong Soo sug: subj: Prostatic Neoplasms Pathology Outcomes (Health Care) Prostatectomy Methods Aged Magnetic Resonance Imaging Methods Middle Age Human Prostatic Neoplasms Therapy Genitalia, Male Pathology Male Retrospective Design Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged: 65+ years Middle Aged: 45-64 years Male ab: Objectives: To investigate whether the apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) could help improve the prediction of insignificant prostate cancer in candidates for active surveillance (AS).Methods: Enrolled in this retrospective study were 287 AS candidates who underwent DW-MRI before radical prostatectomy. Patients were stratified into two groups; Group A consisted of patients with no visible tumour or a suspected tumour ADC value > 0.830 × 10(-3) mm(2)/sec and Group B consisted of patients with a suspected tumour ADC value < 0.830 × 10(-3) mm(2)/sec. We compared pathological outcomes in each group.Results: Group A had 243 (84.7 %) patients and Group B had 44 (15.3 %) patients. The proportion of organ-confined Gleason ≤ 6 disease and insignificant prostate cancer was significantly higher in Group A than Group B (61.3 % vs. 38.6 %, p = 0.005 and 47.7 % vs. 25.0 %, p = 0.005, respectively). On multivariate analysis, a high ADC value was the independent predictor of organ-confined Gleason ≤ 6 disease and insignificant prostate cancer (odds ratio = 2.43, p = 0.011 and odds ratio = 2.74, p = 0.009, respectively).Conclusion: Tumour ADC values may be a useful marker for predicting insignificant prostate cancer in candidates for AS.Key Points: • ADC from DW-MRI can help assess prostate cancer aggressiveness in potential AS candidates. • There was a closed correlation between higher ADC values and insignificant prostate cancer. • The absence of lesions on DWI/DWI can help select potential AS candidates. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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