Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value?
Objective: Certain pulmonary diseases are associated with cardiovascular disease (CVD). Therefore we investigated the incremental predictive value of pulmonary, mediastinal and pleural features over cardiovascular imaging findings.Methods: A total of 10,410 patients underwent diagnostic chest CT for...
| Publicado en: | European Radiology Vol. 25; no. 6; pp. 1646 - 1655 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109732030&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109732030 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2015 vid: 25 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109732030 NLM25773934 2012995383 10.1007/s00330-014-3495-0 NLM25773934 PMC4419189 109732030 ppf: 1646 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? aug: au: Jairam, Pushpa M de Jong, Pim A Mali, Willem P Th M Isgum, Ivana van der Graaf, Yolanda sug: subj: Tomography, X-Ray Computed Methods Cardiovascular Diseases Lung Diseases Lung Diseases Complications Cardiovascular Diseases Complications Diagnosis Female Aged Pleura Middle Age Male Mediastinum Predictive Value of Tests Cox Proportional Hazards Model Human Lung Prospective Studies Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: Certain pulmonary diseases are associated with cardiovascular disease (CVD). Therefore we investigated the incremental predictive value of pulmonary, mediastinal and pleural features over cardiovascular imaging findings.Methods: A total of 10,410 patients underwent diagnostic chest CT for non-cardiovascular indications. Using a case-cohort approach, we visually graded CTs from the cases and from an approximately 10 % random sample of the baseline cohort (n = 1,203) for cardiovascular, pulmonary, mediastinal and pleural findings. The incremental value of pulmonary disease-related CT findings above cardiovascular imaging findings in cardiovascular event risk prediction was quantified by comparing discrimination and reclassification.Results: During a mean follow-up of 3.7 years (max. 7.0 years), 1,148 CVD events (cases) were identified. Addition of pulmonary, mediastinal and pleural features to a cardiovascular imaging findings-based prediction model led to marginal improvement of discrimination (increase in c-index from 0.72 (95 % CI 0.71-0.74) to 0.74 (95 % CI 0.72-0.75)) and reclassification measures (net reclassification index 6.5 % (p < 0.01)).Conclusion: Pulmonary, mediastinal and pleural features have limited predictive value in the identification of subjects at high risk of CVD events beyond cardiovascular findings on diagnostic chest CT scans.Key Points: • Incidental cardiovascular findings on routine chest CT can predict cardiovascular disease • Non-cardiovascular chest CT abnormalities are associated with cardiovascular disease • Non-cardiovascular chest CT features have limited predictive value beyond cardiovascular features. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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