Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice.

Background: The human cardiac action potential in atrial and ventricular cells is initiated by a fast-activating, fast-inactivating sodium current generated by the SCN5A/Nav1.5 channel in association with its β1/SCN1B subunit. The role of Nav1.5 in the etiology of many cardiac diseases strongly sugg...

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Bibliographic Details

Published in:	Heart Rhythm Vol. 12; no. 6; pp. 1333 - 1343
Main Authors:	Daimi, Houria, Lozano-Velasco, Estefania, Haj Khelil, Amel, Chibani, Jemni B E, Barana, Adriana, Amorós, Irene, González de la Fuente, Marta, Caballero, Ricardo, Aranega, Amelia, Franco, Diego
Format:	research Journal Article
Published:	Elsevier B.V. Jun2015
Online Access:	View this record in EBSCOhost