Limitations of parametric modeling of the left ventricle using first harmonic analysis: possible role for gaussian modeling.
Background: Fourier (cosine) analysis of time activity curves (TAC) of radionuclide ventriculography (RVG) may oversimplify the TAC and has limitations.Methods: We identified 21 patients who had undergone 24 frame planar RVG with ejection fractions ranging from 8% to 76% (43% ± 19%). The TAC for eac...
| Publicado en: | Journal of Nuclear Cardiology Vol. 21; no. 4; pp. 723 - 730 |
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| Autor principal: | |
| Formato: | Journal Article |
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Elsevier B.V.
Aug2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109753609&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109753609 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10713581 1YCL jtl: Journal of Nuclear Cardiology issn: 10713581 maglogo: N pubinfo: dt: Aug2014 vid: 21 iid: 4 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 109753609 NLM24810430 2012659872 10.1007/s12350-014-9905-5 NLM24810430 109753609 ppf: 723 ppct: 7 formats: tig: atl: Limitations of parametric modeling of the left ventricle using first harmonic analysis: possible role for gaussian modeling. aug: au: Hansen, Christopher L affil: Section of Cardiology, Jefferson Heart Institute, Thomas Jefferson University, 925 Chestnut Street, Mezzanine, Philadelphia, PA, USA, christopher.hansen@jefferson.edu. sug: subj: Radionuclide Ventriculography Methods Ventricular Function, Left Mathematics Models, Biological ab: Background: Fourier (cosine) analysis of time activity curves (TAC) of radionuclide ventriculography (RVG) may oversimplify the TAC and has limitations.Methods: We identified 21 patients who had undergone 24 frame planar RVG with ejection fractions ranging from 8% to 76% (43% ± 19%). The TAC for each pixel was fitted to both a cosine and gaussian function then analyzed on a pixel-by-pixel basis then over the entire LV. Second, mathematical simulations were performed to analyze the stability of each fit in the presence of low amplitude and noise.Results: The fit was slightly but significantly better for the gaussian compared to the cosine function (RMS gaussian 13.0% ± 2.5% vs 13.5% ± 2.1% cosine; P = .016). There was near exact correlation with amplitude and between gaussian mu and cosine phase. The SD of phase from the cosine fit correlated strongly with the SD of the mu from the gaussian fit. The proposed new measure of dyssynchrony, the sigma parameter of the gaussian fit, correlated with the SD of the cosine phase (r = 0.520, P = .016). Simulations showed gradual but modest deviation of the sigma parameter from the gaussian fit with lower amplitudes whereas the deviation of the calculated SD of phase increased exponentially with decreasing amplitude.Conclusions: First harmonic (cosine) fitting has significant limitations. Gaussian fitting is an alternative way to model the LV TAC. The sigma from the gaussian may provide additional information LV dyssynchrony and is less influenced by image noise. Gaussian fitting merits further evaluation for modeling LV function. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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