Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging study.
Objectives: To investigate structural brain changes in inflammatory bowel disease (IBD).Methods: Brain magnetic resonance imaging (MRI) was performed on 18 IBD patients (aged 45.16 ± 14.71 years) and 20 aged-matched control subjects. The imaging protocol consisted of a sagittal-FLAIR, a T1-weighted...
| Publicado en: | European Radiology Vol. 24; no. 10; pp. 2499 - 2507 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109755086&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109755086 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2014 vid: 24 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109755086 NLM25001084 2012709911 10.1007/s00330-014-3242-6 NLM25001084 109755086 ppf: 2499 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging study. aug: au: Zikou, Anastasia K Kosmidou, Maria Astrakas, Loukas G Tzarouchi, Loukia C Tsianos, Epameinondas Argyropoulou, Maria I affil: Department of Radiology, Medical School, University of Ioannina, Ioannina, Greece. sug: subj: Brain Pathology Brain Diseases Diagnosis Magnetic Resonance Imaging Methods Inflammatory Bowel Diseases Complications Atrophy Diagnosis Atrophy Etiology Brain Diseases Etiology Brain Stem Pathology Female Prospective Studies Frontal Lobe Pathology Human Inflammatory Bowel Diseases Diagnosis Male Middle Age Parietal Lobe Pathology Neural Pathways Pathology ROC Curve Temporal Lobe Pathology Middle Aged: 45-64 years Female Male ab: Objectives: To investigate structural brain changes in inflammatory bowel disease (IBD).Methods: Brain magnetic resonance imaging (MRI) was performed on 18 IBD patients (aged 45.16 ± 14.71 years) and 20 aged-matched control subjects. The imaging protocol consisted of a sagittal-FLAIR, a T1-weighted high-resolution three-dimensional spoiled gradient-echo sequence, and a multisession spin-echo echo-planar diffusion-weighted sequence. Differences between patients and controls in brain volume and diffusion indices were evaluated using the voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) methods, respectively. The presence of white-matter hyperintensities (WMHIs) was evaluated on FLAIR images.Results: VBM revealed decreased grey matter (GM) volume in patients in the fusiform and the inferior temporal gyrus bilaterally, the right precentral gyrus, the right supplementary motor area, the right middle frontal gyrus and the left superior parietal gyrus (p < 0.05). TBSS showed decreased axial diffusivity (AD) in the right corticospinal tract and the right superior longitudinal fasciculus in patients compared with controls. A larger number of WMHIs was observed in patients (p < 0.05).Conclusions: Patients with IBD show an increase in WMHIs and GM atrophy, probably related to cerebral vasculitis and ischaemia. Decreased AD in major white matter tracts could be a secondary phenomenon, representing Wallerian degeneration.Key Points: • There is evidence of central nervous system involvement in IBD. • Diffusion tensor imaging detects microstructural brain abnormalities in IBD. • Voxel based morphometry reveals brain atrophy in IBD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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