Oral sucrose administration to reduce pain response during immunization in 16-19-month infants: a randomized, placebo-controlled trial.

Unlabelled: Although the analgesic effect of sucrose on newborns is well established, little is known about whether these solutions are effective in reducing procedural pain in infants beyond the newborn period. The purpose of this study was to determine the effect of sucrose solution given orally o...

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Publicado en:European Journal of Pediatrics Vol. 173; no. 11; pp. 1527 - 1533
Autores principales: Yilmaz, Gonca, Caylan, Nilgun, Oguz, Melek, Karacan, Can Demir
Formato: research randomized controlled trial Journal Article
Publicado: Springer Nature Nov2014
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov2014
      vid: 173
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      pub: Springer Nature
      place: New York, New York
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        2012764119
        10.1007/s00431-014-2358-7
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        atl: Oral sucrose administration to reduce pain response during immunization in 16-19-month infants: a randomized, placebo-controlled trial.
      aug:
        au:
          Yilmaz, Gonca
          Caylan, Nilgun
          Oguz, Melek
          Karacan, Can Demir
        affil: Department of Social and Developmental Pediatrics, Dr. Sami Ulus Children and Maternity Training Hospital, Birlik Mah. Kahire Cad. 451 Sokak, Zirvekent Mimoza Sitesi A2 Blok, No 54, Çankaya, Ankara, Turkey, goncay31@gmail.com.
      sug:
        subj:
          Analgesia Methods
          Immunization Adverse Effects
          Pain Prevention and Control
          Sucrose Administration and Dosage
          Administration, Oral
          Female
          Human
          Infant
          Male
          Pain Etiology
          Pain Measurement
          Vaccines Administration and Dosage
          Infant: 1-23 months
          Female
          Male
      ab: Unlabelled: Although the analgesic effect of sucrose on newborns is well established, little is known about whether these solutions are effective in reducing procedural pain in infants beyond the newborn period. The purpose of this study was to determine the effect of sucrose solution given orally on infant crying times and measure the distress in a 16-19-month age group. A total of 537 healthy, 16-19-month-old infants attending for their immunizations with intramuscular diphtheria, tetanus, and acellular pertussis (DTaP)/Haemophilus influenza type b/IPV (along with oral polio vaccination (OPV)), intramuscular pneumococcus and intramuscular hepatitis A were randomized to receive 2 mL of a 75 % sucrose solution, a 25 % sucrose solution or sterile water 2 min before injections. Infants receiving a 75 % sucrose solution had significantly reduced total crying times and Children's Hospital of Eastern Ontario Pain Scale scores (CHEOPS) compared with infants in the control and 25 % sucrose solution groups (p < 0.001).Conclusion: Sucrose solution reduces infant distress and is safe and clinically useful even for 16-19-month-old infants.
      pubtype: Academic Journal
      doctype:
        research
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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