Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopic and gastric cancer patients from Northern Brazil.
Background: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA+ and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE).Methods: Sa...
| Publicado en: | BMC Gastroenterology Vol. 14; no. 1; pp. 179 - 180 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109760908&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109760908 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2014 vid: 14 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 109760908 NLM25318991 2012774145 10.1186/1471-230X-14-179 NLM25318991 PMC4286945 109760908 ppf: 179 ppct: 1 formats: tig: atl: Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopic and gastric cancer patients from Northern Brazil. aug: au: de Souza, Carolina Rosal Teixeira de Oliveira, Kátia Soares Ferraz, Jefferson José Sodré Leal, Mariana Ferreira Calcagno, Danielle Queiroz Seabra, Aline Damasceno Khayat, André Salim Montenegro, Raquel Carvalho Alves, Ana Paula Negreiros Nunes Assumpçao, Paulo Pimentel Smith, Marília Cardoso Burbano, Rommel Rodríguez Assumpção, Paulo Pimentel affil: Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa, 01 - Guamá, CEP 66075-110, Caixa postal 479, Belém, PA, Brasil. carolrosalts@gmail.com. sug: subj: Epstein-Barr Virus Infections Diagnosis Gastritis Diagnosis Helicobacter Infections Diagnosis Helicobacter Pylori Stomach Neoplasms Microbiology Adolescence Adult Age Factors Aged Aged, 80 and Over Antigens, Bacterial Analysis Bacterial Proteins Analysis Child Child, Preschool Epstein-Barr Virus Infections Pathology Gastritis Pathology Gastroscopy Helicobacter Infections Pathology Epstein-Barr Virus Infant Middle Age Stomach Stomach Microbiology Stomach Neoplasms Pathology Stomach Neoplasms Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Child: 6-12 years Child, Preschool: 2-5 years Infant: 1-23 months Middle Aged: 45-64 years ab: Background: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA+ and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE).Methods: Samples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA by a urease test and PCR. The presence of EBV was detected by Eber-1 in situ hybridization.Results: In UE, 85.5% of juvenile patients showed some degree of gastritis (45.3% of patients with mild gastritis and 54.7% with moderate/severe gastritis) and patients with mild gastritis were younger than patients with moderate/severe gastritis. Among adults, 48.7% presented mild gastritis and 51.3% moderate/severe gastritis. HP infection was detected in 0% of normal mucosa, 58.5% of juvenile gastritis patients, 69.2% of adult gastritis patients and 88% of GC patients. In these same groups, HP CagA+ was detected in 0%, 37.7%, 61.5% and 67.2% of tissue samples, respectively. In juvenile patients, HP infection was more common in those with gastritis than in normal samples (p = 0.004). The patients with either HP or HP CagA+ were older than patients without these pathogens (p < 0.05). In juvenile patients, HP infection was more frequent in cases of moderate/severe gastritis than in cases of mild gastritis (p = 0.026). Moreover, in patients with GC, HP infection was more frequent in males than in females (p = 0.023). GC patients with HP CagA+ were older than patients with HP CagA- (p = 0.027). HP CagA+ was more common in intestinal-type than diffuse-type GC (p = 0.012). HP CagA+ was also associated with lymph-node (p = 0.024) and distal (p = 0.005) metastasis. No association between EBV infection and HP infection or any clinicopathological variable was detected.Conclusions: Our results suggest that HP is involved in the pathophysiology of severe gastric lesions and in the development of GC, particularly when CagA+ is present. EBV was not the primary pathogenic factor in our samples. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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