Factors associated with quality of life measured by EQ-5D in patients with nontuberculous mycobacterial pulmonary disease.
Purpose: The impact of pulmonary nontuberculous mycobacterial (pNTM) disease on health-related quality of life (HRQoL) has not received significant attention in the literature. In this study, we compared the HRQoL in patients with pNTM disease and healthy subjects and identified influencing factors...
| Publicado en: | Quality of Life Research Vol. 23; no. 10; pp. 2735 - 2742 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109762516&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109762516 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09629343 GPQ jtl: Quality of Life Research issn: 09629343 maglogo: N pubinfo: dt: Dec2014 vid: 23 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109762516 NLM24908057 2012788698 10.1007/s11136-014-0727-3 NLM24908057 109762516 ppf: 2735 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Factors associated with quality of life measured by EQ-5D in patients with nontuberculous mycobacterial pulmonary disease. aug: au: Hong, Ji Young Lee, Sang A Kim, Song Yee Chung, Kyung Soo Moon, Sung Woo Kim, Eun Young Jung, Ji Ye Park, Moo Suk Kim, Young Sam Kim, Se Kyu Chang, Joon Kang, Young Ae affil: Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun-gu, Seoul, 120-752, Republic of Korea. sug: subj: Mycobacterium Infections Psychosocial Factors Quality of Life Psychosocial Factors Tuberculosis, Pulmonary Psychosocial Factors Adult Aged Aged, 80 and Over Anxiety Psychosocial Factors Case Control Studies Depression Psychosocial Factors Female Forced Expiratory Volume Physiology Health Status Health Status Indicators Human Male Middle Age Multivariate Analysis Questionnaires Regression Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: The impact of pulmonary nontuberculous mycobacterial (pNTM) disease on health-related quality of life (HRQoL) has not received significant attention in the literature. In this study, we compared the HRQoL in patients with pNTM disease and healthy subjects and identified influencing factors using EuroQol 5D (EQ-5D) data.Methods: The present study used an age- and sex-matched case-control analysis from a cohort of 85 pNTM patients and 340 participants from a national survey. Baseline EQ-5D utility scores and EQ-5D visual analog scale (VAS) scores were measured in both groups. In patients with pNTM disease, the factors affecting EQ-5D were identified using multiple linear regression analysis.Results: While the median EQ-5D VAS scores were lower in pNTM patients than in the control subjects (pNTM, 70; control, 80; P < 0.001), the median EQ-5D utility scores were similar in two groups (both, 1.000, P = 0.878). Interestingly, the percentage of subjects reporting problems on the anxiety/depression dimension was higher for patients with pNTM disease (18.8 %) compared with the control subjects (11.5 %, P = 0.07). In multivariate analysis, increasing severity of forced expired volume in one second (FEV1) decline was associated with a significant decrease in EQ-5D scores of pNTM patients.Conclusions: This study suggested the EQ-5D may not be useful instrument in pNTM patients due to ceiling effect of EQ-5D and mild disease activity. Patients with pNTM disease tended to report more reduced health status and more problems with anxiety/depression than the healthy controls. Lung function, measured by FEV1, was independently associated with EQ-5D scores in patients with pNTM disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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