Thalamic volume deficit contributes to procedural and explicit memory impairment in HIV infection with primary alcoholism comorbidity.
Component cognitive and motor processes contributing to diminished visuomotor procedural learning in HIV infection with comorbid chronic alcoholism (HIV+ALC) include problems with attention and explicit memory processes. The neural correlates associated with this constellation of cognitive and motor...
| Publicado en: | Brain Imaging & Behavior Vol. 8; no. 4; pp. 611 - 621 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109765228&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109765228 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2014 vid: 8 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109765228 NLM24421067 2012815609 10.1007/s11682-013-9286-4 NLM24421067 PMC4097992 109765228 ppf: 611 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Thalamic volume deficit contributes to procedural and explicit memory impairment in HIV infection with primary alcoholism comorbidity. aug: au: Fama, Rosemary Rosenbloom, Margaret J Sassoon, Stephanie A Rohlfing, Torsten Pfefferbaum, Adolf Sullivan, Edith V sug: subj: Alcoholism Pathology Alcoholism Psychosocial Factors HIV Infections Pathology HIV Infections Psychosocial Factors Memory Disorders Pathology Thalamus Pathology Adult Alcoholism Complications Attention Comorbidity HIV Infections Complications Hippocampus Pathology Human Learning Magnetic Resonance Imaging Male Memory Memory Disorders Etiology Middle Age Neuropsychological Tests Body Weights and Measures Psychomotor Performance Regression Adult: 19-44 years Middle Aged: 45-64 years Male ab: Component cognitive and motor processes contributing to diminished visuomotor procedural learning in HIV infection with comorbid chronic alcoholism (HIV+ALC) include problems with attention and explicit memory processes. The neural correlates associated with this constellation of cognitive and motor processes in HIV infection and alcoholism have yet to be delineated. Frontostriatal regions are affected in HIV infection, frontothalamocerebellar regions are affected in chronic alcoholism, and frontolimbic regions are likely affected in both; all three of these systems have the potential of contributing to both visuomotor procedural learning and explicit memory processes. Here, we examined the neural correlates of implicit memory, explicit memory, attention, and motor tests in 26 HIV+ALC (5 with comorbidity for nonalcohol drug abuse/dependence) and 19 age-range matched healthy control men. Parcellated brain volumes, including cortical, subcortical, and allocortical regions, as well as cortical sulci and ventricles, were derived using the SRI24 brain atlas. Results indicated that smaller thalamic volumes were associated with poorer performance on tests of explicit (immediate and delayed) and implicit (visuomotor procedural) memory in HIV+ALC. By contrast, smaller hippocampal volumes were associated with lower scores on explicit, but not implicit memory. Multiple regression analyses revealed that volumes of both the thalamus and the hippocampus were each unique independent predictors of explicit memory scores. This study provides evidence of a dissociation between implicit and explicit memory tasks in HIV+ALC, with selective relationships observed between hippocampal volume and explicit but not implicit memory, and highlights the relevance of the thalamus to mnemonic processes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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