Non-contrast MRI perfusion angiosome in diabetic feet.
Objective: The purpose of this study is to develop a non-contrast magnetic resonance imaging (MRI) approach to evaluate skeletal muscle perfusion in the diabetic foot based on the concept of angiosomes of the foot.Methods: Five healthy volunteers and five participants with diabetes (HbA1c = 7.2 ± 1....
| Publicado en: | European Radiology Vol. 25; no. 1; pp. 99 - 106 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109768987&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109768987 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2015 vid: 25 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109768987 NLM25100334 2012825770 10.1007/s00330-014-3337-0 NLM25100334 109768987 ppf: 99 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Non-contrast MRI perfusion angiosome in diabetic feet. aug: au: Zheng, Jie Hastings, Mary K Muccigross, David Fan, Zhaoyang Gao, Fabao Curci, John Hildebolt, Charles F Mueller, Michael J affil: Mallinckrodt Institute of Radiology, Cardiovascular Imaging Lab, 510 South Kingshighway Blvd. Campus Box 8225, St. Louis, MO, 63110, USA, zhengj@mir.wustl.edu. sug: subj: Diabetic Foot Pathology Foot Blood Supply Muscle, Skeletal Blood Supply Aged Analysis of Variance Contrast Media Diagnostic Use Pilot Studies Human Magnetic Resonance Angiography Methods Middle Age Muscle, Skeletal Physiopathology Peripheral Vascular Diseases Pathology Prospective Studies Aged: 65+ years Middle Aged: 45-64 years ab: Objective: The purpose of this study is to develop a non-contrast magnetic resonance imaging (MRI) approach to evaluate skeletal muscle perfusion in the diabetic foot based on the concept of angiosomes of the foot.Methods: Five healthy volunteers and five participants with diabetes (HbA1c = 7.2 ± 1.8%) without a history of peripheral artery disease were examined. The non-contrast perfusion measurements were performed during a toe flexion challenge. Absolute perfusion maps were created and two regions (medial and lateral) on the maps were segmented based on angiosomes.Result: Regional difference in the perfusion of foot muscle was readily visualized in the MRI perfusion angiosomes during the challenge. In the participants with diabetes, the perfusion during toe flexion challenge was significantly lower than in healthy volunteers (P < 0.01). The average perfusion for the medial plantar region of the right foot was lower in subjects with diabetes (38 ± 9 ml/min/100 g) than in healthy subjects (93 ± 33 ml/min/100 g).Conclusions: Non-contrast MRI perfusion angiosome maps demonstrate the feasibility of determining regional perfusion in foot muscles during toe challenge and may facilitate evaluation of muscle perfusion in diabetic feet.Key Points: • Non-contrast MRI perfusion angiosome maps measure regional perfusion in foot muscles non-invasively. • Foot perfusion response to challenge is reduced in persons with diabetes. • MRI perfusion angiosome maps may help evaluation of regional foot muscle perfusion. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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