Comparison of the quantitative CT imaging biomarkers of idiopathic pulmonary fibrosis at baseline and early change with an interval of 7 months.
Rationale and Objectives: Median survival of patients with idiopathic pulmonary fibrosis (IPF) is 2-5 years. Sensitive imaging metrics can play a role in detecting early changes in therapeutic development. The aim of the present study was to compare known computed tomography (CT) histogram kurtosis...
| Publicado en: | Academic Radiology Vol. 22; no. 1; pp. 70 - 81 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109769742&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109769742 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10766332 T4X jtl: Academic Radiology issn: 10766332 maglogo: N pubinfo: dt: Jan2015 vid: 22 iid: 1 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 109769742 NLM25262954 2012837245 10.1016/j.acra.2014.08.004 NLM25262954 109769742 ppf: 70 ppct: 11 formats: tig: atl: Comparison of the quantitative CT imaging biomarkers of idiopathic pulmonary fibrosis at baseline and early change with an interval of 7 months. aug: au: Kim, Hyun J Brown, Matthew S Chong, Daniel Gjertson, David W Lu, Peiyun Kim, Hak J Coy, Heidi Goldin, Jonathan G sug: subj: Idiopathic Pulmonary Fibrosis Radiography Radiographic Image Enhancement Methods Radiographic Image Interpretation, Computer-Assisted Methods Severity of Illness Indices Tomography, X-Ray Computed Methods Disease Progression Early Diagnosis Female Human Prospective Studies Male Reproducibility of Results Sensitivity and Specificity Female Male ab: Rationale and Objectives: Median survival of patients with idiopathic pulmonary fibrosis (IPF) is 2-5 years. Sensitive imaging metrics can play a role in detecting early changes in therapeutic development. The aim of the present study was to compare known computed tomography (CT) histogram kurtosis and a classifier-based quantitative score to assess baseline severity and change over time in patients with IPF. Materials and Methods: A total of 57 patients with at least baseline and paired follow-up scans were selected from an imaging database of standardized CT scans obtained from patients with IPF. CT histogram measurement of kurtosis and quantitative lung fibrosis (QLF) and quantitative interstitial lung disease (QILD) scores from a classification algorithm were calculated. Spearman rank correlations were used to assess associations between baseline severity and changes for all CT-derived measures compared to forced vital capacity (FVC) and carbon monoxide diffusion capacity (DLCO) (percent predicted). Results: At baseline, mean (±SD) of kurtosis was 2.43 (±1.83). Mean (±SD) values of QLF and QILD scores were 20.7% (±13.4) and 43.3% (±20.0), respectively. All baseline histogram indices and QLF and QILD scores were correlated well with baseline FVC and DLCO. When assessing associations with changes in FVC and DLCO over time, only QLF score was statistically significant (ρ = -0.57; P < .0001 for FVC and ρ = -0.34; P = .025 for DLCO), whereas kurtosis was not. Conclusions: Classifier-model-derived scores (QLF and QILD), based on a set of texture features, are associated with baseline disease extent and are also a sensitive measure of change over time. A QLF score can be used for measuring the extent of disease severity and longitudinal changes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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