Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients.

Objectives: Polymorphisms in the lysosomal transporter encoded by the pfcrt gene directly impact on Plasmodium falciparum susceptibility to aminoquinolines. The Lys76Thr mutation is the critical change conferring chloroquine resistance in vitro and in vivo, but always occurs with additional non-syno...

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Publicado en:	Journal of Antimicrobial Chemotherapy (JAC) Vol. 70; no. 1; pp. 116 - 124
Autores principales:	Gadalla, Nahla B, Malmberg, Maja, Adam, Ishag, Oguike, Mary C, Beshir, Khalid, Elzaki, Salah-Eldin, Mukhtar, Izdihar, Gadalla, Amal A, Warhurst, David C, Ngasala, Billy, Mårtensson, Andreas, El-Sayed, Badria B, Gil, J Pedro, Sutherland, Colin J
Formato:	research Journal Article
Publicado:	Oxford University Press / USA Jan2015
Acceso en línea:	Ver este registro en EBSCOhost