Atorvastatin treatment and carotid plaque morphology in first-ever atherosclerotic transient ischemic attack/stroke: a case-control study.
Background: A relationship between echolucency of carotid plaques and the consequent risk of ipsilateral ischemic stroke has been observed. An aggressive lipid-lowering therapy may increase the echogenicity of carotid plaque in patients with elevated low-density lipoprotein cholesterol levels. The a...
| Publicado en: | Journal of Stroke & Cerebrovascular Diseases Vol. 24; no. 1; pp. 138 - 144 |
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| Autores principales: | , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
W B Saunders
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109771185&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109771185 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10523057 DOU jtl: Journal of Stroke & Cerebrovascular Diseases issn: 10523057 maglogo: N pubinfo: dt: Jan2015 vid: 24 iid: 1 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 109771185 109771185 NLM25440329 2012841366 10.1016/j.jstrokecerebrovasdis.2014.08.006 NLM25440329 109771185 ppf: 138 ppct: 6 formats: tig: atl: Atorvastatin treatment and carotid plaque morphology in first-ever atherosclerotic transient ischemic attack/stroke: a case-control study. aug: au: Marchione, Pasquale Vento, Claudio Morreale, Manuela Izzo, Chiara Maugeri, Andrea Manuppella, Federica Romeo, Tommaso Giacomini, Patrizia sug: subj: Carotid Artery Diseases Drug Therapy Carotid Artery Diseases Pathology Fatty Acids Therapeutic Use Antilipemic Agents Therapeutic Use Cerebral Ischemia, Transient Drug Therapy Cerebral Ischemia, Transient Pathology Atherosclerosis Drug Therapy Atherosclerosis Pathology Heterocyclic Compounds Therapeutic Use Stroke Drug Therapy Stroke Pathology Aged Carotid Artery Diseases Ultrasonography Case Control Studies Dose-Response Relationship, Drug Female Fatty Acids Adverse Effects Human Antilipemic Agents Adverse Effects Image Processing, Computer Assisted Cerebral Ischemia, Transient Ultrasonography Male Middle Age Atherosclerosis Ultrasonography Prospective Studies Heterocyclic Compounds Adverse Effects Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: A relationship between echolucency of carotid plaques and the consequent risk of ipsilateral ischemic stroke has been observed. An aggressive lipid-lowering therapy may increase the echogenicity of carotid plaque in patients with elevated low-density lipoprotein cholesterol levels. The aim of this study is to prospectively evaluate the long-term effect of high-dose atorvastatin on carotid plaque morphology in patients with first-ever transient ischemic attack or stroke. Methods: All patients with symptomatic first ischemic atherosclerotic cerebrovascular event occurred within the previous 10 days were enrolled. Carotid Doppler ultrasound of the neck vessels with 7-11 MHz probe for the definition of the atherosclerotic carotid framework was performed. The analysis of the gray-scale median (GSM) of each plate was carried out with image processing software. Results: A total of 240 symptomatic plaques were included and divided into 3 groups: 80 in group A (atorvastatin 80 mg), 80 in group B (atorvastatin 40 mg), and 80 to group C (no atorvastatin). GSM score increases significantly more extensive in group A than in group B (+48.65 vs. +39.46, P < .02) and group C (+48.65 vs. 19.3, P = .0002). An inverse association between reduction of low-density lipoprotein and the increase in the GSM score (r = -.456, P = .007) has been observed. Moreover, the reduction of high-sensitive C-reactive protein correlates inversely with the increase of the GSM (r = -.398, P = .021). Conclusions: Dose-dependent effect of atorvastatin on symptomatic carotid plaque morphology may suggest a specific role of this drug in the atherosclerotic stroke prevention. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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