MR volumetric assessment of endolymphatic hydrops.
Objectives: We aimed to volumetrically quantify endolymph and perilymph spaces of the inner ear in order to establish a methodological basis for further investigations into the pathophysiology and therapeutic monitoring of Menière's disease.Methods: Sixteen patients (eight females, aged 38-71 years)...
| Publicado en: | European Radiology Vol. 25; no. 2; pp. 585 - 596 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109774224&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109774224 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2015 vid: 25 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109774224 NLM25319347 2012873617 10.1007/s00330-014-3414-4 NLM25319347 109774224 ppf: 585 ppct: 11 formats: fmt: @attributes: type: P tig: atl: MR volumetric assessment of endolymphatic hydrops. aug: au: Gürkov, R Berman, A Dietrich, O Flatz, W Jerin, C Krause, E Keeser, D Ertl-Wagner, B sug: subj: Ear, Inner Pathology Endolymphatic Hydrops Diagnosis Image Processing, Computer Assisted Magnetic Resonance Imaging Methods Adult Aged Algorithms Female Human Male Middle Age Prospective Studies Reproducibility of Results Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: We aimed to volumetrically quantify endolymph and perilymph spaces of the inner ear in order to establish a methodological basis for further investigations into the pathophysiology and therapeutic monitoring of Menière's disease.Methods: Sixteen patients (eight females, aged 38-71 years) with definite unilateral Menière's disease were included in this study. Magnetic resonance (MR) cisternography with a T2-SPACE sequence was combined with a Real reconstruction inversion recovery (Real-IR) sequence for delineation of inner ear fluid spaces. Machine learning and automated local thresholding segmentation algorithms were applied for three-dimensional (3D) reconstruction and volumetric quantification of endolymphatic hydrops. Test-retest reliability was assessed by the intra-class coefficient; correlation of cochlear endolymph volume ratio with hearing function was assessed by the Pearson correlation coefficient.Results: Endolymph volume ratios could be reliably measured in all patients, with a mean (range) value of 15% (2-25) for the cochlea and 28% (12-40) for the vestibulum. Test-retest reliability was excellent, with an intra-class coefficient of 0.99. Cochlear endolymphatic hydrops was significantly correlated with hearing loss (r = 0.747, p = 0.001).Conclusions: MR imaging after local contrast application and image processing, including machine learning and automated local thresholding, enable the volumetric quantification of endolymphatic hydrops. This allows for a quantitative assessment of the effect of therapeutic interventions on endolymphatic hydrops.Key Points: • Endolymphatic hydrops is the pathological hallmark of Menière's disease. • Endolymphatic hydrops can be visualized by locally enhanced ultra-high-resolution MR imaging. • Computer-aided image processing enables quantification of endolymphatic hydrops. • Endolymphatic hydrops correlates with hearing loss in patients with Menière's disease. • Therapeutic trials in Menière's disease can be monitored with this quantitative approach. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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