Examining the latent class structure of CO2 hypersensitivity using time course trajectories of panic response systems.
Background and Objectives: Carbon dioxide (CO2) hypersensitivity is hypothesized to be a robust endophenotypic marker of panic spectrum vulnerability. The goal of the current study was to explore the latent class trajectories of three primary response systems theoretically associated with CO2 hypers...
| Published in: | Journal of Behavior Therapy & Experimental Psychiatry Vol. 47; pp. 68 - 77 |
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| Main Authors: | , , , , |
| Format: | research Journal Article |
| Published: |
Pergamon Press - An Imprint of Elsevier Science
Jun2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109776257&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109776257 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00057916 JIG jtl: Journal of Behavior Therapy & Experimental Psychiatry issn: 00057916 maglogo: N pubinfo: dt: Jun2015 vid: 47 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 109776257 NLM25496936 2012896815 10.1016/j.jbtep.2014.10.013 NLM25496936 PMC4324118 109776257 ppf: 68 ppct: 9 formats: tig: atl: Examining the latent class structure of CO2 hypersensitivity using time course trajectories of panic response systems. aug: au: Roberson-Nay, Roxann Beadel, Jessica R Gorlin, Eugenia I Latendresse, Shawn J Teachman, Bethany A sug: subj: Anxiety Diagnosis Carbon Dioxide Adverse Effects Panic Disorder Diagnosis Respiratory Hypersensitivity Psychosocial Factors Adolescence Adult Anxiety Chemically Induced Anxiety Psychosocial Factors Carbon Dioxide Administration and Dosage Female Human Male Middle Age Panic Disorder Chemically Induced Panic Disorder Psychosocial Factors Psychological Tests Respiratory Hypersensitivity Chemically Induced Respiratory Rate Drug Effects Risk Factors Time Factors Young Adult Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background and Objectives: Carbon dioxide (CO2) hypersensitivity is hypothesized to be a robust endophenotypic marker of panic spectrum vulnerability. The goal of the current study was to explore the latent class trajectories of three primary response systems theoretically associated with CO2 hypersensitivity: subjective anxiety, panic symptoms, and respiratory rate (fR).Methods: Participants (n = 376; 56% female) underwent a maintained 7.5% CO2 breathing task that included three phases: baseline, CO2 air breathing, and recovery. Growth mixture modeling was used to compare response classes (1…n) to identify the best-fit model for each marker. Panic correlates also were examined to determine class differences in panic vulnerability.Results: For subjective anxiety ratings, a three-class model was selected, with individuals in one class reporting an acute increase in anxiety during 7.5% CO2 breathing and a return to pre-CO2 levels during recovery. A second, smaller latent class was distinguished by elevated anxiety across all three phases. The third class reported low anxiety reported during room air, a mild increase in anxiety during 7.5% CO2 breathing, and a return to baseline during recovery. Latent class trajectories for fR yielded one class whereas panic symptom response yielded two classes.Limitations: This study examined CO2 hypersensitivity in one of the largest samples to date, but did not ascertain a general population sample thereby limiting generalizability. Moreover, a true resting baseline measure of fR was not measured.Conclusions: Two classes potentially representing different risk pathways were observed. Implications of results will be discussed in the context of panic risk research. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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