Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR.
Objective: Our objective was to evaluate pathological and functional changes in chronic kidney disease (CKD) using diffusion tensor imaging (DTI) at 3 T.Methods: There were fifty-one patients with CKD who required biopsy and 19 healthy volunteers who were examined using DTI at 3 T. The mean values o...
| Publicado en: | European Radiology Vol. 25; no. 3; pp. 652 - 661 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109776632&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109776632 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2015 vid: 25 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109776632 NLM25304821 2012906459 10.1007/s00330-014-3461-x NLM25304821 109776632 ppf: 652 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR. aug: au: Liu, Zhiling Xu, Ying Zhang, Jie Zhen, Junhui Wang, Rong Cai, Shifeng Yuan, Xianshun Liu, Qingwei affil: Department of Radiology, Provincial Hospital Affiliated to Shandong University, Shandong University, 324# Jingwu Weiqi Road, Jinan, People's Republic of China. sug: subj: Kidney Pathology Renal Insufficiency, Chronic Pathology Adolescence Adult Biopsy Magnetic Resonance Imaging Methods Female Glomerular Filtration Rate Physiology Human Male Middle Age Prospective Studies Renal Insufficiency, Chronic Physiopathology Young Adult Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: Our objective was to evaluate pathological and functional changes in chronic kidney disease (CKD) using diffusion tensor imaging (DTI) at 3 T.Methods: There were fifty-one patients with CKD who required biopsy and 19 healthy volunteers who were examined using DTI at 3 T. The mean values of fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were obtained from the renal parenchyma (cortex and medulla). Correlations between imaging results and the estimated glomerular filtration rate (eGFR), as well as pathological damage (glomerular lesion and tubulointerstitial injury), were evaluated.Results: The renal cortical FA was significantly lower than the medullary in both normal and affected kidneys (p < 0.001). The parenchymal FA was significantly lower in patients than healthy controls, regardless of whether eGFR was reduced. There were positive correlations between eGFR and FA (cortex, r = 0.689, p = 0.000; and medulla, r = 0.696, p = 0.000), and between eGFR and ADC (cortex, r = 0.310, p = 0.017; and medulla, r = 0.356, p = 0.010). Negative correlations were found between FA and the glomerular lesion (cortex, r = -0.499, p = 0.000; and medulla, r = -0.530, p = 0.000), and between FA and tubulointerstitial injury (cortex, r = -0.631, p = 0.000; and medulla, r = -0.724, p = 0.000).Conclusion: DTI is valuable for noninvasive assessment of renal function and pathology in patients with CKD. A decrease in FA could identify the glomerular lesions, tubulointerstitial injuries, and eGFR. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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