Reduced white matter integrity and cognitive deficits in maintenance hemodialysis ESRD patients: a diffusion-tensor study.
Objectives: The purpose of this investigation was to examine the association between cognition disorders and microstructural white matter (WM) changes in maintenance hemodialysis end-stage renal disease (ESRD) patients.Methods: Twenty-six maintenance hemodialysis ESRD patients and 28 healthy control...
| Publicado en: | European Radiology Vol. 25; no. 3; pp. 661 - 669 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109776642&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109776642 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2015 vid: 25 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109776642 NLM25326436 2012906468 10.1007/s00330-014-3466-5 NLM25326436 109776642 ppf: 661 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Reduced white matter integrity and cognitive deficits in maintenance hemodialysis ESRD patients: a diffusion-tensor study. aug: au: Zhang, Ruijie Liu, Kai Yang, Linfeng Zhou, Tao Qian, Shaowen Li, Bo Peng, Zhaohui Li, Min Sang, Shengpeng Jiang, Qingjun Sun, Gang affil: Department of Medical Imaging, Jinan Military General Hospital, No.25, Shifan Road, Jinan, Shandong Province, China, 250031. sug: subj: Cognition Disorders Etiology Kidney Failure, Chronic Complications Brain Diseases Pathology Hemodialysis Adverse Effects Adult Cerebral Edema Complications Case Control Studies Cognition Disorders Magnetic Resonance Imaging Methods Female Human Kidney Failure, Chronic Pathology Brain Diseases Psychosocial Factors Male Middle Age Neuropsychological Tests Young Adult Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: The purpose of this investigation was to examine the association between cognition disorders and microstructural white matter (WM) changes in maintenance hemodialysis end-stage renal disease (ESRD) patients.Methods: Twenty-six maintenance hemodialysis ESRD patients and 28 healthy controls underwent diffusion tensor imaging (DTI), Mini Mental State Examination (MMSE), Trial Marking Test-A&B (TMT-A&B), and white matter hyperintensity (WMH) assessment. Tract-based spatial statistics (TBSS) analyses was performed to evaluate WM changes in the patients. Relationships between behavioural performances, clinical data, and the DTI index were tested, respectively, by correlation analysis at the voxel level.Results: ESRD patients showed significant decreased fractional anisotropy (FA) in 14 WM regions, and increased mean diffusivity (MD) and radial diffusivity (RD) in widespread regions. Significant positive correlations between FA values and MMSE scores were found in the right anterior corona radiata and the left anterior thalamic radiation; significant negative correlations between the TMT-B time consumption and FA values were identified in the bilateral superior longitudinal fasciculus. Positive linear relationships between MD, RD values, and the duration of hemodialysis were found in several WM regions.Conclusion: Structural damages to radiation and associative fibre tracts, caused by brain oedema and WM demyelination, may account for the cognitive deficits in ESRD patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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