Comparison of the utility of Cocaine- and Amphetamine-Regulated Transcript (CART), chromogranin A, and chromogranin B in neuroendocrine tumor diagnosis and assessment of disease progression.
Context: Prognosis in patients with neuroendocrine tumors (NETs) is often poor, frequently reflecting delayed diagnosis. Hence, accurate and practical NET markers are needed. Cocaine- and amphetamine-regulated transcript (CART) peptide is a potential novel NET marker.Design and Participants: Circula...
| Publicado en: | Journal of Clinical Endocrinology & Metabolism Vol. 100; no. 4; pp. 1520 - 1529 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
2015 Apr
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109780265&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109780265 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0021972X 1GG jtl: Journal of Clinical Endocrinology & Metabolism issn: 0021972X maglogo: N pubinfo: dt: 2015 Apr vid: 100 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 109780265 109780265 NLM25664601 2012963336 10.1210/jc.2014-3640 NLM25664601 109780265 ppf: 1520 ppct: 9 formats: tig: atl: Comparison of the utility of Cocaine- and Amphetamine-Regulated Transcript (CART), chromogranin A, and chromogranin B in neuroendocrine tumor diagnosis and assessment of disease progression. aug: au: Ramachandran, R Bech, P Murphy, K G Caplin, M E Patel, M Vohra, S Khan, M S Dhillo, W S Sharma, R Palazzo, F F Win, Z Tan, T Khoo, B Meeran, K Frilling, A Ghatei, M A Bloom, S R Martin, N M sug: subj: Adrenal Gland Neoplasms Diagnosis Protein Precursors Blood Nerve Tissue Proteins Blood Neuroendocrine Tumors Diagnosis Paraganglioma Diagnosis Pheochromocytoma Diagnosis Tumor Markers, Biological Blood Adrenal Gland Neoplasms Blood Adult Aged Aged, 80 and Over Case Control Studies Disease Progression Female Human Male Middle Age Neuroendocrine Tumors Blood Paraganglioma Blood Pheochromocytoma Blood Predictive Value of Tests Prognosis Retrospective Design Young Adult Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Context: Prognosis in patients with neuroendocrine tumors (NETs) is often poor, frequently reflecting delayed diagnosis. Hence, accurate and practical NET markers are needed. Cocaine- and amphetamine-regulated transcript (CART) peptide is a potential novel NET marker.Design and Participants: Circulating levels of CART peptide and the established NET markers chromogranin A (CgA) and chromogranin B (CgB) were measured using RIA in 353 patients with NET (normal renal function) and in controls. Clinical data were collected retrospectively.Main Outcome Measure(s): The comparative and combined utility of CART, CgA, and CgB for diagnosis and assessment of disease progression was measured in different NET subtypes.Results: CgA and CgB in combination improved diagnostic accuracy in patients with gut NETs, nongastroenteropancreatic NETs, and NETs with an unknown primary origin compared with each biomarker alone. Measuring CART did not further improve diagnosis in these NET subtypes. For pancreatic NETs, CgB was superior to CgA and CART in detecting stable disease (P < .007), whereas CgA and CART in combination were most effective in identifying progressive disease. In phaeochromocytomas/paragangliomas (PCC/PGL), CART was the most useful biomarker for identifying stable (P < .001) and progressive (P = .001) disease. Consistent with this, plasma CART decreased following PCC/PGL tumor resection, remaining low in all patients in remission, but increasing in those with progressive disease.Conclusions: CART is a useful marker for identifying progressive pancreatic NETs. CART is superior to CgA and CgB in detecting stable and progressive PCC/PGLs, and may have a role as a surveillance marker for PCC/PGL patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|