Early Detection of High Oxidative Activity in Patients With Adenomatous Intestinal Polyps and Colorectal Adenocarcinoma: Myeloperoxidase and Oxidized Low-Density Lipoprotein in Serum as New Markers of Oxidative Stress in Colorectal Cancer.
Objectives: To detect whether signs of oxidative stress appear at early stages of colorectal adenocarcinoma (CRC), particularly in the polyp stage. We also aimed to evaluate the specific entities myeloperoxidase (MPO) and oxidized low-density lipoprotein (oxLDL) as novel markers of oxidation in the...
| Published in: | Laboratory Medicine Vol. 46; no. 2; pp. 123 - 136 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
Spring2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109798501&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109798501 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00075027 4CY jtl: Laboratory Medicine issn: 00075027 maglogo: N pubinfo: dt: Spring2015 vid: 46 iid: 2 pid: 10398 pub: Oxford University Press / USA artinfo: ui: 109798501 103195999 10.1309/LMZJJU6BC86WUDHW NLM25918191 109798501 ppf: 123 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Early Detection of High Oxidative Activity in Patients With Adenomatous Intestinal Polyps and Colorectal Adenocarcinoma: Myeloperoxidase and Oxidized Low-Density Lipoprotein in Serum as New Markers of Oxidative Stress in Colorectal Cancer. aug: au: Crespo-Sanjuán, Jesús Calvo-Nieves, María D. Aguirre-Gervás, Beatriz Herreros-Rodríguez, José Velayos-Jiménez, Benito Castro-Alija, María J. Muñoz-Moreno, María F. Sánchez, Diego Zamora-González, Nuria Bajo-Grañeras, Raquel García-Centeno, Rosa M. Cabrerizo, María E. Largo Bustamante, María R. Garrote-Adrados, José A. affil: Department of Clinical Laboratory, Clinical Hospital University of Valladolid, Valladolid, Spain sug: subj: Colorectal Neoplasms Metabolism Adenocarcinoma Metabolism Adenomatous Polyps Metabolism Oxidative Stress Evaluation Tumor Markers, Biological Blood Oxidoreductases Blood Lycopene Blood beta Carotene Blood Survival Lipoproteins, LDL Cholesterol Blood Lipoproteins, HDL Cholesterol Blood Clinical Assessment Tools Comparative Studies T-Tests Data Analysis Software Analysis of Variance Chi Square Test Fisher's Exact Test Pearson's Correlation Coefficient Multivariate Analysis Logistic Regression Kaplan-Meier Estimator Survival Analysis Middle Age Aged Female Male Human Funding Source Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objectives: To detect whether signs of oxidative stress appear at early stages of colorectal adenocarcinoma (CRC), particularly in the polyp stage. We also aimed to evaluate the specific entities myeloperoxidase (MPO) and oxidized low-density lipoprotein (oxLDL) as novel markers of oxidation in the plasma of patients with CRC and to study the relationship between oxidative status in plasma and patient survival. Methods: We assayed serum or plasma specimens from healthy control subjects (n = 14), from patients with intestinal polyps (n = 39), and from patients with CRC (n = 128) to calculate the modified oxidative balance score (MOBS) using several serum markers (β-carotene, lycopene, vitamin A, vitamin E, MPO, and oxLDL). We also assayed the levels of C-reactive protein (CRP) and obtained lipid profiles. Finally, we studied the survival of patients in relationship to oxidative status (antioxidants and pro-oxidants) and inflammation markers, and added theses data to the lipid profile for each patient. Results: Oxidative stress levels increased as disease stage advanced. This increase was detected early in the polyp stage, before polyps progressed to cancer, and could be measured by the increase of such new markers as MPO and oxLDL, the decrease in antioxidants, and the MOBS value. Higher levels of oxidation correlated with lower survival. Conclusion: The oxidation process, which can cause mutations leading to CRC, begins development in the polyp stage. This process may be detected early by monitoring serum markers such as MPO and oxLDL. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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