A study of diffusion tensor imaging in Duchenne muscular dystrophy.
Objective To observe the white matter and gray matter impairment of Duchenne muscular dstrophy (DMD) patients with diffusion tensor imaging (DTI). Methods Forteen male patients with DMD (6-11 years old) and 10 age - matched healthy boys participated into this study. All patients' diagnosis was based...
| Publicado en: | Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 15; no. 5; pp. 369 - 374 |
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| Autores principales: | , |
| Formato: | abstract diagnostic images research tables/charts Journal Article |
| Publicado: |
Chinese Journal of Contemporary Neurology & Neurosurgery
May2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109812425&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109812425 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16726731 FDQ6 jtl: Chinese Journal of Contemporary Neurology & Neurosurgery issn: 16726731 maglogo: N pubinfo: dt: May2015 vid: 15 iid: 5 pid: 80951 pub: Chinese Journal of Contemporary Neurology & Neurosurgery artinfo: ui: 109812425 103440098 10.3969/j.issn.1672-6731.2015.05.006 109812425 ppf: 369 ppct: 5 formats: fmt: @attributes: type: P tig: atl: A study of diffusion tensor imaging in Duchenne muscular dystrophy. aug: au: FU Ya WU Shi-wen affil: Department of Neurology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China sug: subj: Diagnostic Imaging Muscular Dystrophy, Duchenne Diagnosis Technology, Medical Neurology Neurosurgery Human Brain Diffusion of Innovation Magnetic Resonance Imaging Muscular Dystrophy, Duchenne Symptoms Patient Selection Creatine Kinase Isoenzymes Electromyography Brain Anatomy and Histology ab: Objective To observe the white matter and gray matter impairment of Duchenne muscular dstrophy (DMD) patients with diffusion tensor imaging (DTI). Methods Forteen male patients with DMD (6-11 years old) and 10 age - matched healthy boys participated into this study. All patients' diagnosis was based on typical signs and symptoms, serum creatine kinase (CK), electromyography, multiplex ligation-dependent probe amplification (MLPA) for DMD gene test and muscle biopsy results. All participants were scanned by DTI. The fractional anisotropy (FA) values of regions of interest (ROIs), including bilateral parietal lobe white matter, bilateral frontal lobe white matter, genu of corpus callosum, splenium of corpus callosum, bilateral caput nuclei caudati, bilateral anterior cingulate gyrus, bilateral cingulate gyrus, bilateral posterior cingulate gyrus, bilateral lenticular nucleus, bilateral anterior limb of internal capsule, bilateral posterior limb of internal capsule, bilateral thalamus, bilateral occipital lobe white matter, bilateral temporal lobe white matter, bilateral hippocampus, bilateral superior cerebellar peduncle and bilateral middle cerebellar peduncle, were measured. The data was analyzed and compared between control group and DMD group. Results Compared with control group, the FA value of splenium of corpus callosum in DMD group was significantly reduced (t = - 2.187, P = 0.045). No significant difference was found in FA values of other ROIs between 2 groups (P > 0.05, for all). Conclusions It is found in China for the first time that DMD patients had microstructural changes in splenium of corpus callosum. However, the correlation between this change and cognitive changes of DMD patients remains to be further studied. pubtype: Academic Journal doctype: abstract diagnostic images research tables/charts Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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