Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes.
Tumor angiogenesis and metastasis are the major causes for high morbidity and mortality rates in cancer patient. Modulation on tumor angiogenesis and metastasis provides opportunities to halt progression of cancer. From our previous findings,Phyllanthusplant possesses antiproliferative effects on me...
| Published in: | Nutrition & Cancer Vol. 67; no. 5; pp. 783 - 796 |
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| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
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Taylor & Francis Ltd
Jul2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109813149&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109813149 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Jul2015 vid: 67 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 109813149 103547151 10.1080/01635581.2015.1040518 NLM25996262 109813149 ppf: 783 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes. aug: au: Tang, Yin-Quan Jaganath, Indu Bala Manikam, Rishya Sekaran, Shamala Devi affil: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia sug: subj: Neovascularization, Pathologic Plants, Medicinal Therapeutic Use Matrix Metalloproteinases Nutrition Vascular Endothelial Growth Factor A Neoplasm Metastasis Melanoma Prevention and Control Prostatic Neoplasms Prevention and Control Male Plant Extracts Melanoma Therapy Prostatic Neoplasms Therapy Cell Culture Techniques Endothelium Cell Migration Inhibition Data Analysis Data Analysis Software T-Tests Cell Movement Male ab: Tumor angiogenesis and metastasis are the major causes for high morbidity and mortality rates in cancer patient. Modulation on tumor angiogenesis and metastasis provides opportunities to halt progression of cancer. From our previous findings,Phyllanthusplant possesses antiproliferative effects on melanoma and prostate cancer cell lines and induction of apoptosis. The main aims of the present work were further investigated on the antimetastatic and antiangiogenic effects on cancer cells (MeWo and PC-3) and human umbilical vein endothelial cells (HUVECs) of 4Phyllanthusspecies (P.amarus, P.niruri, P.urinariaandP.watsonii).Phyllanthusextracts significantly inhibited cell adhesion, migration, invasion, and transendothelial migration activities of cancer (MeWo and PC-3) cells in a dose-dependent manner (P< 0.05) by cell-matrix adhesion, Transwell migration, invasion, and transendothelial migration assays.Phyllanthusextracts were exhibited low cytotoxicity on HUVECs up to a concentration of 500.0 μg/ml by MTS reduction assay.Phyllanthusextracts also exhibited antiangiogenic effects through inhibition of migration, invasion, and microcapillary like-tube structure formation in HUVECs. These observations were due to alteration in activities of matrix metalloproteinase (MMP) −2, −7, −9, and −26 in treated-endothelial and cancer cells by zymographies. These findings suggest thatPhyllanthusplant has the potential to inhibit tumour metastasis and angiogenesis through the suppression of MMP enzymes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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