Reduced cortical surface area in adolescents with conduct disorder.
Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder and psychopathy in adulthood. Neuroimaging research has identified abnormal cortical volume (CV) in CD. However, CV comprises two genetically and developmentally separable components: cortical thi...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 24; no. 8; pp. 909 - 918 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109823301&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109823301 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Aug2015 vid: 24 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109823301 108720037 10.1007/s00787-014-0639-3 NLM25481508 109823301 ppf: 909 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Reduced cortical surface area in adolescents with conduct disorder. aug: au: Sarkar, Sagari Daly, Eileen Feng, Yue Ecker, Christine Craig, Michael Harding, Duncan Deeley, Quinton Murphy, Declan affil: Sackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, London SE5 8AF UK sug: subj: Child Behavior Disorders Physiopathology Brain Abnormalities Brain Anatomy and Histology Cerebral Cortex Human Magnetic Resonance Imaging Methods Adolescence Male Child Young Adult Scales Descriptive Statistics Data Analysis Software Funding Source Adolescent: 13-18 years Child: 6-12 years Male ab: Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder and psychopathy in adulthood. Neuroimaging research has identified abnormal cortical volume (CV) in CD. However, CV comprises two genetically and developmentally separable components: cortical thickness (CT) and surface area (SA). Aim of this study is to explore the relationship between the cortical constituents of CV in boys with CD. We applied FreeSurfer software to structural MRI data to derive measures of CV, CT, and SA in 21 boys with CD and 19 controls. Relationships between these cortical measures were investigated. Boys with CD had significantly reduced CV and SA compared to non-CD boys in ventromedial and dorsolateral prefrontal cortex. We found no significant between-group differences in CT. Reduced prefrontal CV in boys with CD is associated with significantly reduced SA in the same regions. This finding may help to identify specific neurodevelopmental mechanisms underlying cortical deficits observed in CD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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