Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project.
Background: Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases. Objectives: In this study we evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardio...
| Publicado en: | Environmental Health Perspectives Vol. 123; no. 8; pp. 785 - 792 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Aug2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109824556&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109824556 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Aug2015 vid: 123 iid: 8 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 109824556 108735544 10.1289/ehp.1408224 NLM25816055 PMC4529004 109824556 ppf: 785 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project. aug: au: Lanki, Timo Hampel, Regina Tiittanen, Pekka Andrich, Silke Beelen, Rob Brunekreef, Bert Dratva, Julia De Faire, Ulf Fuks, Kateryna B. Hoffmann, Barbara Imboden, Medea Jousilahti, Pekka Koenig, Wolfgang Mahabadi, Amir A. Künzli, Nino Pedersen, Nancy L. Penell, Johanna Pershagen, Göran Probst-Hensch, Nicole M. Schaffner, Emmanuel sug: subj: Air Pollution Inflammation Etiology Motor Vehicles Particulate Matter Cardiovascular Risk Factors In Adulthood Human Europe Descriptive Statistics Confidence Intervals Cross Sectional Studies Linear Regression C-Reactive Protein Blood Fibrinogen Blood Carbon Nitrogen Oxides Data Analysis Software Multicenter Studies Middle Age Male Female Residence Characteristics Funding Source Adult Adolescence Aged Aged, 80 and Over Middle Aged: 45-64 years Adult: 19-44 years Adolescent: 13-18 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases. Objectives: In this study we evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardiovascular disease. Methods: Six cohorts of adults from Central and Northern Europe were used in this crosssectional study as part of the larger ESCAPE project (European Study of Cohorts for Air Pollution Effects). Data on levels of blood markers for systemic inflammation—high-sensitivity C-reactive protein (CRP) and fibrinogen—were available for 22,561 and 17,428 persons, respectively. Land use regression models were used to estimate cohort participants' long-term exposure to various size fractions of PM, soot, and nitrogen oxides (NOx). In addition, traffic intensity on the closest street and traffic load within 100 m from home were used as indicators of traffic air pollution exposure. Results: Particulate air pollution was not associated with systemic inflammation. However, cohort participants living on a busy (> 10,000 vehicles/day) road had elevated CRP values (10.2%; 95% CI: 2.4, 18.8%, compared with persons living on a quiet residential street with < 1,000 vehicles/day). Annual NOx concentration was also positively associated with levels of CRP (3.2%; 95% CI: 0.3, 6.1 per 20 μg/m3), but the effect estimate was more sensitive to model adjustments. For fibrinogen, no consistent associations were observed. Conclusions: Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|