A systematic review of methods of uncertainty analysis and their applications in the assessment of chemical exposures, effects, and risks.
Methods of uncertainty analysis are being included increasingly in regulatory chemical risk assessment. Although best practices have been established by several safety agencies in Europe and the United States, they exist only in the grey literature – there has been no comprehensive analysis of the s...
| Publicado en: | International Journal of Environmental Health Research Vol. 25; no. 5; pp. 522 - 551 |
|---|---|
| Autor principal: | |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109824868&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109824868 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Oct2015 vid: 25 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 109824868 108789328 10.1080/09603123.2014.980782 NLM25409755 109824868 ppf: 522 ppct: 29 formats: fmt: @attributes: type: P tig: atl: A systematic review of methods of uncertainty analysis and their applications in the assessment of chemical exposures, effects, and risks. aug: au: Maxim, Laura affil: Institut des Sciences de la Communication (UMS 3665), CNRS (Centre National de la Recherche Scientifique), Université Paris Sorbonne, UPMC (Université Pierre et Marie Curie), Paris, France sug: subj: Uncertainty Data Analysis, Statistical Methods Environmental Exposure Risk Factors Hazardous Materials Adverse Effects Risk Assessment Human Probability Knowledge Bases Public Health Administration Hazardous Materials Legislation and Jurisprudence Hazardous Materials Legislation and Jurisprudence European Union United States Funding Source ab: Methods of uncertainty analysis are being included increasingly in regulatory chemical risk assessment. Although best practices have been established by several safety agencies in Europe and the United States, they exist only in the grey literature – there has been no comprehensive analysis of the scientific, peer-reviewed literature on these methods. We therefore conducted a systematic review of the recent peer-reviewed literature (2007–2013) on uncertainty analysis relevant to chemical risks. The main objective was to determine whether current methods are robust enough for regulatory use, because the methods used to protect public health must meet the most stringent scientific standards. Based on 297 papers, we concluded that the peer-reviewed literature is much more critical about the disadvantages of those methods, compared to the grey literature. Furthermore, uncertainty analyses can be influenced significantly by subjective expert judgment. As a suggested improvement, we developed guidelines for transparent reporting of uncertainty assessment results. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|